Alternative titles; symbols
HGNC Approved Gene Symbol: ALDH1B1
Cytogenetic location: 9p13.1 Genomic coordinates (GRCh38): 9:38,392,702-38,398,661 (from NCBI)
The 2 aldehyde dehydrogenase isozymes that play a major role in ethanol detoxification, ALDH1 (100640) and ALDH2 (100650), are cytosolic and mitochondrial forms, respectively. Their organization is basically similar; their sizes are 53 kb and 44 kb, respectively, and both contain 13 coding exons interrupted by introns of comparable lengths. Hsu et al. (1989) cloned a novel ALDH gene, ALDH5, from a cosmid human DNA library. Although it contains no introns, Northern blot hybridization of human liver RNA revealed a unique mRNA component that hybridized with this gene probe but with neither the ALDH1 probe or the ALDH2 probe. ALDH5 encodes a deduced 517-amino acid protein that shares 70.6% and 62.8% sequence identity with the ALDH2 and ALDH1 proteins, respectively.
Hsu and Chang (1991) provided a full report on the ALDH5 gene, which they referred to as ALDHx.
Hsu et al. (1989) assigned the ALDH5 gene to chromosome 9 by Southern blot analysis of rodent-human hybrid cell DNAs. By in situ hybridization, Hiraoka et al. (1995) mapped the ALDH5 gene to 9p13.
Harada, S., Agarwal, D. P., Goedde, H. W. Electrophoretic and biochemical studies of human aldehyde dehydrogenase isozymes in various tissues. Life Sci. 26: 1773-1780, 1980. [PubMed: 6985464] [Full Text: https://doi.org/10.1016/0024-3205(80)90577-9]
Hiraoka, L. R., Hsu, L., Hsieh, C.-L. Assignment of ALDH3 to human chromosome 17p11.2 and ALDH5 to human chromosome 9p13. Genomics 25: 323-325, 1995. [PubMed: 7774944] [Full Text: https://doi.org/10.1016/0888-7543(95)80150-k]
Hsu, L. C., Chang, W.-C., Yoshida, A. Cloning of a new human aldehyde dehydrogenase gene and comparison with liver cytosolic ALDH1 and mitochondrial ALDH2 genes. (Abstract) Am. J. Hum. Genet. 45 (suppl.): A196 only, 1989.
Hsu, L. C., Chang, W. C. Cloning and characterization of a new functional human aldehyde dehydrogenase gene. J. Biol. Chem. 266: 12257-12265, 1991. [PubMed: 2061311]