* 102670

MUCOSAL VASCULAR ADDRESSIN CELL ADHESION MOLECULE 1; MADCAM1


Alternative titles; symbols

ADDRESSIN, MUCOSAL
MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; MACAM1


HGNC Approved Gene Symbol: MADCAM1

Cytogenetic location: 19p13.3     Genomic coordinates (GRCh38): 19:496,486-505,343 (from NCBI)


TEXT

Description

MADCAM1 is a member of the superfamily of immunoglobulin-like proteins and is involved in formation of the anatomic organization of the splenic marginal zone (Pabst et al., 2000).


Cloning and Expression

Tissue-specific homing of lymphocytes is regulated by interactions with the endothelium of specialized venules, such as the high endothelial venules (HEV) in lymph nodes and mucosal lymphoid tissues. The mucosal vascular addressin, a 58- to 66-kD glycoprotein adhesion receptor for lymphocytes, is selectively expressed on HEV of the mucosal lymphoid organ and on lamina propria venules and helps direct lymphocyte traffic to these mucosal tissues. Briskin et al. (1993) isolated a mouse cDNA that, on transfection into COS cells, encoded immunoreactive addressin that specifically bound a mucosal HEV-binding T-cell lymphoma. The predicted amino acid sequence defines the mucosal addressin as a novel immunoglobulin family member with 2 N-terminal domains that display strong homology to previously described vascular adhesion receptors for leukocytes: ICAM1 (147840) and VCAM1 (192225). The membrane proximal domain is homologous to the third domain of another mucosa-associated member of the immunoglobulin family, namely, IgA1 (see 146900).

Leung et al. (1997) established that the previously reported human MACAM1 cDNA (Leung et al., 1996; Shyjan et al., 1996) encodes the human homolog of the mouse mucosal addressin protein, despite gross dissimilarities in the C-terminal structures of the proteins.


Mapping

By PCR-based analysis of somatic cell hybrids, Leung et al. (1997) mapped the MACAM1 gene to chromosome 19; by FISH, they regionalized the assignment to 19p13.3 in close proximity to the ICAM1 and ICAM3 (146631) genes.


Animal Model

Pabst et al. (2000) reported that Nkx2.3 (606727) knockout mice lacked expression of Madcam1. Using cotransfection experiments, they demonstrated that Nkx2.3 could activate Madcam1 transcription and concluded that loss of Madcam1 expression was at least partly responsible for the migration and homing defects of lymphocytes and macrophages seen in Nkx2.3-deficient mice.


REFERENCES

  1. Briskin, M. J., McEvoy, L. M., Butcher, E. C. MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1. Nature 363: 461-464, 1993. [PubMed: 8502297, related citations] [Full Text]

  2. Leung, E., Berg, R. W., Langley, R., Greene, J., Raymond, L. A., Augustus, M., Ni, J., Carter, K. C., Spurr, N., Choo, K. H. A., Krissansen, G. W. Genomic organization, chromosomal mapping, and analysis of the 5-prime promoter region of the human MAdCAM-1 gene. Immunogenetics 46: 111-119, 1997. [PubMed: 9162097, related citations] [Full Text]

  3. Leung, E., Greene, J., Ni, J., Raymond, L. G., Lehnert, K., Langley, R., Krissansen, G. W. Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts. Immun. Cell Biol. 74: 490-496, 1996. [PubMed: 8989586, related citations] [Full Text]

  4. Pabst, O., Forster, R., Lipp, M., Engel, H., Arnold, H.-H. NKX2.3 is required for MAdCAM-1 expression and homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. EMBO J. 19: 2015-2023, 2000. [PubMed: 10790368, images, related citations] [Full Text]

  5. Shyjan, A. M., Bertagnolli, M., Kenney, C. J., Briskin, M. J. Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences. J. Immun. 156: 2851-2857, 1996. [PubMed: 8609404, related citations]


Dawn Watkins-Chow - updated : 02/27/2002
Victor A. McKusick - updated : 8/26/1997
Creation Date:
Victor A. McKusick : 6/22/1993
alopez : 02/02/2024
mgross : 02/27/2002
carol : 1/11/2002
mgross : 2/11/2000
carol : 8/25/1999
dholmes : 9/30/1997
jenny : 9/5/1997
terry : 8/26/1997
carol : 6/22/1993

* 102670

MUCOSAL VASCULAR ADDRESSIN CELL ADHESION MOLECULE 1; MADCAM1


Alternative titles; symbols

ADDRESSIN, MUCOSAL
MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; MACAM1


HGNC Approved Gene Symbol: MADCAM1

Cytogenetic location: 19p13.3     Genomic coordinates (GRCh38): 19:496,486-505,343 (from NCBI)


TEXT

Description

MADCAM1 is a member of the superfamily of immunoglobulin-like proteins and is involved in formation of the anatomic organization of the splenic marginal zone (Pabst et al., 2000).


Cloning and Expression

Tissue-specific homing of lymphocytes is regulated by interactions with the endothelium of specialized venules, such as the high endothelial venules (HEV) in lymph nodes and mucosal lymphoid tissues. The mucosal vascular addressin, a 58- to 66-kD glycoprotein adhesion receptor for lymphocytes, is selectively expressed on HEV of the mucosal lymphoid organ and on lamina propria venules and helps direct lymphocyte traffic to these mucosal tissues. Briskin et al. (1993) isolated a mouse cDNA that, on transfection into COS cells, encoded immunoreactive addressin that specifically bound a mucosal HEV-binding T-cell lymphoma. The predicted amino acid sequence defines the mucosal addressin as a novel immunoglobulin family member with 2 N-terminal domains that display strong homology to previously described vascular adhesion receptors for leukocytes: ICAM1 (147840) and VCAM1 (192225). The membrane proximal domain is homologous to the third domain of another mucosa-associated member of the immunoglobulin family, namely, IgA1 (see 146900).

Leung et al. (1997) established that the previously reported human MACAM1 cDNA (Leung et al., 1996; Shyjan et al., 1996) encodes the human homolog of the mouse mucosal addressin protein, despite gross dissimilarities in the C-terminal structures of the proteins.


Mapping

By PCR-based analysis of somatic cell hybrids, Leung et al. (1997) mapped the MACAM1 gene to chromosome 19; by FISH, they regionalized the assignment to 19p13.3 in close proximity to the ICAM1 and ICAM3 (146631) genes.


Animal Model

Pabst et al. (2000) reported that Nkx2.3 (606727) knockout mice lacked expression of Madcam1. Using cotransfection experiments, they demonstrated that Nkx2.3 could activate Madcam1 transcription and concluded that loss of Madcam1 expression was at least partly responsible for the migration and homing defects of lymphocytes and macrophages seen in Nkx2.3-deficient mice.


REFERENCES

  1. Briskin, M. J., McEvoy, L. M., Butcher, E. C. MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1. Nature 363: 461-464, 1993. [PubMed: 8502297] [Full Text: https://doi.org/10.1038/363461a0]

  2. Leung, E., Berg, R. W., Langley, R., Greene, J., Raymond, L. A., Augustus, M., Ni, J., Carter, K. C., Spurr, N., Choo, K. H. A., Krissansen, G. W. Genomic organization, chromosomal mapping, and analysis of the 5-prime promoter region of the human MAdCAM-1 gene. Immunogenetics 46: 111-119, 1997. [PubMed: 9162097] [Full Text: https://doi.org/10.1007/s002510050249]

  3. Leung, E., Greene, J., Ni, J., Raymond, L. G., Lehnert, K., Langley, R., Krissansen, G. W. Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts. Immun. Cell Biol. 74: 490-496, 1996. [PubMed: 8989586] [Full Text: https://doi.org/10.1038/icb.1996.81]

  4. Pabst, O., Forster, R., Lipp, M., Engel, H., Arnold, H.-H. NKX2.3 is required for MAdCAM-1 expression and homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. EMBO J. 19: 2015-2023, 2000. [PubMed: 10790368] [Full Text: https://doi.org/10.1093/emboj/19.9.2015]

  5. Shyjan, A. M., Bertagnolli, M., Kenney, C. J., Briskin, M. J. Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences. J. Immun. 156: 2851-2857, 1996. [PubMed: 8609404]


Contributors:
Dawn Watkins-Chow - updated : 02/27/2002
Victor A. McKusick - updated : 8/26/1997

Creation Date:
Victor A. McKusick : 6/22/1993

Edit History:
alopez : 02/02/2024
mgross : 02/27/2002
carol : 1/11/2002
mgross : 2/11/2000
carol : 8/25/1999
dholmes : 9/30/1997
jenny : 9/5/1997
terry : 8/26/1997
carol : 6/22/1993