* 104752

SERUM AMYLOID A4; SAA4


Alternative titles; symbols

AMYLOID A, SERUM, 4
SERUM AMYLOID A4, CONSTITUTIVE


HGNC Approved Gene Symbol: SAA4

Cytogenetic location: 11p15.1     Genomic coordinates (GRCh38): 11:18,231,355-18,236,802 (from NCBI)


TEXT

Description

The acute phase reactant serum amyloid A (SAA) is a polymorphic apolipoprotein encoded by a family of highly homologous and closely linked genes (summary by Steel et al., 1993). For background information on SAA, see SAA1 (104750).


Cloning and Expression

Studying protein and cDNA, Whitehead et al. (1992) identified a member of the serum amyloid A protein superfamily, designated SAA4, as constitutive apolipoprotein of high density lipoprotein.

Watson et al. (1992) analyzed the derived protein structure of SAA4.


Gene Structure

Watson et al. (1992) analyzed the structure of the SAA4 gene.

Steel et al. (1993) determined that the SAA4 gene shares the same 5-prime to 3-prime orientation and has the characteristic 4-exon structure of the other members of the SAA superfamily.


Mapping

Steel et al. (1993) demonstrated that the SAA4 gene is located 9 kb downstream of the SAA2 gene (104751) on chromosome 11.

By fluorescence in situ hybridization using a cosmid probe carrying the SAA2 and SAA4 genes, Sellar et al. (1994) localized these genes to 11p15.1.

De Beer et al. (1996) found that in the mouse the Saa4 gene is linked to the serum amyloid A gene family on chromosome 7.


REFERENCES

  1. de Beer, M. C., de Beer, F. C., Gerardot, C. J., Cecil, D. R., Webb, N. R., Goodson M. L., Kindy, M. S. Structure of the mouse Saa4 gene and its linkage to the serum amyloid A gene family. Genomics 34: 139-142, 1996. [PubMed: 8661036, related citations] [Full Text]

  2. Sellar, G. C., Jordan, S. A., Bickmore, W. A., Fantes, J. A., van Heyningen, V., Whitehead, A. S. The human serum amyloid A protein (SAA) superfamily gene cluster: mapping to chromosome 11p15.1 by physical and genetic linkage analysis. Genomics 19: 221-227, 1994. [PubMed: 8188252, related citations] [Full Text]

  3. Steel, D. M., Sellar, G. C., Uhlar, C. M., Simon, S., de Beer, F. C., Whitehead, A. S. A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA1). Genomics 16: 447-454, 1993. [PubMed: 7686132, related citations] [Full Text]

  4. Watson, G., Coade, S., Woo, P. Analysis of the genomic and derived protein structure of a novel human serum amyloid A gene, SAA4. Scand. J. Immun. 36: 703-712, 1992. [PubMed: 1439582, related citations] [Full Text]

  5. Whitehead, A. S., de Beer, M. C., Steel, D. M., Rits, M., Lelias, J. M., Lane, W. S., de Beer, F. C. Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein. J. Biol. Chem. 267: 3862-3867, 1992. [PubMed: 1740433, related citations]


Creation Date:
Victor A. McKusick : 3/9/1993
carol : 05/02/2022
carol : 03/09/2022
carol : 03/08/2022
alopez : 07/16/2012
alopez : 7/16/2012
alopez : 12/9/1998
terry : 6/5/1996
terry : 6/3/1996
mark : 8/8/1995
carol : 4/12/1994
carol : 5/21/1993
carol : 3/23/1993
carol : 3/9/1993

* 104752

SERUM AMYLOID A4; SAA4


Alternative titles; symbols

AMYLOID A, SERUM, 4
SERUM AMYLOID A4, CONSTITUTIVE


HGNC Approved Gene Symbol: SAA4

Cytogenetic location: 11p15.1     Genomic coordinates (GRCh38): 11:18,231,355-18,236,802 (from NCBI)


TEXT

Description

The acute phase reactant serum amyloid A (SAA) is a polymorphic apolipoprotein encoded by a family of highly homologous and closely linked genes (summary by Steel et al., 1993). For background information on SAA, see SAA1 (104750).


Cloning and Expression

Studying protein and cDNA, Whitehead et al. (1992) identified a member of the serum amyloid A protein superfamily, designated SAA4, as constitutive apolipoprotein of high density lipoprotein.

Watson et al. (1992) analyzed the derived protein structure of SAA4.


Gene Structure

Watson et al. (1992) analyzed the structure of the SAA4 gene.

Steel et al. (1993) determined that the SAA4 gene shares the same 5-prime to 3-prime orientation and has the characteristic 4-exon structure of the other members of the SAA superfamily.


Mapping

Steel et al. (1993) demonstrated that the SAA4 gene is located 9 kb downstream of the SAA2 gene (104751) on chromosome 11.

By fluorescence in situ hybridization using a cosmid probe carrying the SAA2 and SAA4 genes, Sellar et al. (1994) localized these genes to 11p15.1.

De Beer et al. (1996) found that in the mouse the Saa4 gene is linked to the serum amyloid A gene family on chromosome 7.


REFERENCES

  1. de Beer, M. C., de Beer, F. C., Gerardot, C. J., Cecil, D. R., Webb, N. R., Goodson M. L., Kindy, M. S. Structure of the mouse Saa4 gene and its linkage to the serum amyloid A gene family. Genomics 34: 139-142, 1996. [PubMed: 8661036] [Full Text: https://doi.org/10.1006/geno.1996.0253]

  2. Sellar, G. C., Jordan, S. A., Bickmore, W. A., Fantes, J. A., van Heyningen, V., Whitehead, A. S. The human serum amyloid A protein (SAA) superfamily gene cluster: mapping to chromosome 11p15.1 by physical and genetic linkage analysis. Genomics 19: 221-227, 1994. [PubMed: 8188252] [Full Text: https://doi.org/10.1006/geno.1994.1051]

  3. Steel, D. M., Sellar, G. C., Uhlar, C. M., Simon, S., de Beer, F. C., Whitehead, A. S. A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA1). Genomics 16: 447-454, 1993. [PubMed: 7686132] [Full Text: https://doi.org/10.1006/geno.1993.1209]

  4. Watson, G., Coade, S., Woo, P. Analysis of the genomic and derived protein structure of a novel human serum amyloid A gene, SAA4. Scand. J. Immun. 36: 703-712, 1992. [PubMed: 1439582] [Full Text: https://doi.org/10.1111/j.1365-3083.1992.tb03131.x]

  5. Whitehead, A. S., de Beer, M. C., Steel, D. M., Rits, M., Lelias, J. M., Lane, W. S., de Beer, F. C. Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein. J. Biol. Chem. 267: 3862-3867, 1992. [PubMed: 1740433]


Creation Date:
Victor A. McKusick : 3/9/1993

Edit History:
carol : 05/02/2022
carol : 03/09/2022
carol : 03/08/2022
alopez : 07/16/2012
alopez : 7/16/2012
alopez : 12/9/1998
terry : 6/5/1996
terry : 6/3/1996
mark : 8/8/1995
carol : 4/12/1994
carol : 5/21/1993
carol : 3/23/1993
carol : 3/9/1993