Entry - 131190 - ENDOGENOUS RETROVIRAL POL-LIKE SEQUENCE-1; ERPL1 - OMIM

 
 
131190

ENDOGENOUS RETROVIRAL POL-LIKE SEQUENCE-1; ERPL1


Alternative titles; symbols

ONCOGENE HLM2


Cytogenetic location: 1pter-p36     Genomic coordinates (GRCh38): 1:1-27,600,000


TEXT

▼ Cloning and Expression

Callahan et al. (1985) identified a novel class of human endogenous retrovirus. In the study of a representative, HLM2, they found that the proviral genome is a mosaic of retroviral-related sequences: the env gene sequences are closely related to type A virus; LTR sequences are most homologous to type D virus and pol gene sequences are related to each of these as well as to mammalian type B and avian type C viral genomes.


▼ Mapping

HLM2 was assigned to chromosome 1 by studies in somatic cell hybrids (Callahan et al., 1985).

Hall et al. (1987) found evidence for loose linkage with Rh. HLM2 is probably distal to Rh because PGM (which is linked to Rh on its centromeric side) and HLM2 were not closely linked.

▼ REFERENCES

  1. Callahan, R., Chiu, I.-M., Wong, J. F. H., Tronick, S. R., Roe, B. A., Aaronson, S. A., Schlom, J. A new class of endogenous human retroviral genomes. Science 228: 1208-1211, 1985. [PubMed: 2408338, related citations] [Full Text]

  2. Hall, J., Huey, B., Morrow, J., King, M.-C. Polymorphism of HLM2 and linkage relationships on chromosome 1pter-p34. (Abstract) Cytogenet. Cell Genet. 46: 626 only, 1987.


Creation Date:
Victor A. McKusick : 6/4/1986
Edit History:
carol : 02/06/2020
alopez : 02/19/2014
supermim : 3/16/1992
carol : 4/30/1991
supermim : 3/20/1990
ddp : 10/26/1989
root : 6/9/1988
marie : 3/25/1988

131190

ENDOGENOUS RETROVIRAL POL-LIKE SEQUENCE-1; ERPL1


Alternative titles; symbols

ONCOGENE HLM2


Cytogenetic location: 1pter-p36     Genomic coordinates (GRCh38): 1:1-27,600,000


TEXT

Cloning and Expression

Callahan et al. (1985) identified a novel class of human endogenous retrovirus. In the study of a representative, HLM2, they found that the proviral genome is a mosaic of retroviral-related sequences: the env gene sequences are closely related to type A virus; LTR sequences are most homologous to type D virus and pol gene sequences are related to each of these as well as to mammalian type B and avian type C viral genomes.


Mapping

HLM2 was assigned to chromosome 1 by studies in somatic cell hybrids (Callahan et al., 1985).

Hall et al. (1987) found evidence for loose linkage with Rh. HLM2 is probably distal to Rh because PGM (which is linked to Rh on its centromeric side) and HLM2 were not closely linked.

REFERENCES

  1. Callahan, R., Chiu, I.-M., Wong, J. F. H., Tronick, S. R., Roe, B. A., Aaronson, S. A., Schlom, J. A new class of endogenous human retroviral genomes. Science 228: 1208-1211, 1985. [PubMed: 2408338] [Full Text: https://doi.org/10.1126/science.2408338]

  2. Hall, J., Huey, B., Morrow, J., King, M.-C. Polymorphism of HLM2 and linkage relationships on chromosome 1pter-p34. (Abstract) Cytogenet. Cell Genet. 46: 626 only, 1987.


Creation Date:
Victor A. McKusick : 6/4/1986

Edit History:
carol : 02/06/2020
alopez : 02/19/2014
supermim : 3/16/1992
carol : 4/30/1991
supermim : 3/20/1990
ddp : 10/26/1989
root : 6/9/1988
marie : 3/25/1988



NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 5, 2024