Alternative titles; symbols
HGNC Approved Gene Symbol: IL1R2
Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:101,991,960-102,028,544 (from NCBI)
McMahan et al. (1991) used an expression cloning method to isolate human and murine cDNA clones encoding the type II IL1 receptor. The mature receptor was found to consist of a ligand-binding portion composed of 3 immunoglobulin-like domains, a single transmembrane region, and a short cytoplasmic domain of 29 amino acids. The last contrasts with the 215 amino acid cytoplasmic domain of the type I receptor (IL1RA; 147810) and suggests that the 2 receptors may interact with different signal transduction pathways. Both IL1 receptors appear to be well conserved in evolution and map to the same chromosomal region. The molecular mass of the type I receptor is about 80,000; that of the type II receptor is about 60,000.
Colotta et al. (1993) reported results they interpreted as indicating that interleukin-1 acts on myelomonocytic cells through the type I receptor and that the type II receptor inhibits IL1 activity by acting as a decoy target for IL1.
Dale and Nicklin (1999) showed by radiation hybrid mapping that IL1R1 (147810), IL1R2, IL1RL2 (604512), IL1RL1 (601203), and IL18R1 (604494) map to 2q12 and are transcribed in the same direction, with IL1R2 being transcribed towards the cluster.
McMahan et al. (1991) mapped the type II IL1 receptor to chromosome 2q12-q22 by study of somatic cell hybrids and in situ hybridization. IL1A (147760) and IL1B (147720), the human genes for interleukin-1, map to 2q13-q21. The two IL1R genes map to mouse chromosome 1; in contrast to the human, the mouse Il1 genes map to a separate chromosome, i.e., chromosome 2.
Hao et al. (2004) conducted a large-scale case-control study exploring the associations of 426 single-nucleotide polymorphisms (SNPs) with preterm delivery (PTD) in 300 mothers with PTD and 458 mothers with term deliveries. Twenty-five candidate genes were included in the final haplotype analysis. Gene haplotypes at IL1R2 in blacks, NOS2A (163730) in whites, and OPRM1 (600018) in Hispanics were only associated with PTD in these specific ethnic groups.
Colotta, F., Re, F., Muzio, M., Bertini, R., Polentarutti, N., Sironi, M., Giri, J. G., Dower, S. K., Sims, J. E., Mantovani, A. Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science 261: 472-475, 1993. [PubMed: 8332913] [Full Text: https://doi.org/10.1126/science.8332913]
Dale, M., Nicklin, M. J. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. Genomics 57: 177-179, 1999. [PubMed: 10191101] [Full Text: https://doi.org/10.1006/geno.1999.5767]
Hao, K., Wang, X., Niu, T., Xu, X., Li, A., Chang, W., Wang, L., Li, G., Laird, N., Xu., X. A candidate gene association study on preterm delivery: application of high-throughput genotyping technology and advanced statistical methods. Hum. Molec. Genet. 13: 683-691, 2004. [PubMed: 14976157] [Full Text: https://doi.org/10.1093/hmg/ddh091]
McMahan, C. J., Slack, J. L., Mosley, B., Cosman, D., Lupton, S. D., Brunton, L. L., Grubin, C. E., Wignall, J. M., Jenkins, N. A., Brannan, C. I., Copeland, N. G., Huebner, K., Croce, C. M., Cannizzaro, L. A., Benjamin, D., Dower, S. K., Spriggs, M. K., Sims, J. E. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J. 10: 2821-2832, 1991. [PubMed: 1833184] [Full Text: https://doi.org/10.1002/j.1460-2075.1991.tb07831.x]