Entry - 167959 - HUMAN PAPILLOMAVIRUS TYPE 18 INTEGRATION SITE 1; HPV18I1 - OMIM

 
 
167959

HUMAN PAPILLOMAVIRUS TYPE 18 INTEGRATION SITE 1; HPV18I1


Alternative titles; symbols

PAPILLOMAVIRUS TYPE 18 INTEGRATION SITE 1


HGNC Approved Gene Symbol: HPV18I1

Cytogenetic location: 8q24     Genomic coordinates (GRCh38): 8:116,700,001-145,138,636


▼ TEXT

In 2 cervical carcinoma cell lines, HeLa and C4-I, Durst et al. (1987) found that HPV18 DNA was integrated into chromosome 8, 5-prime to the MYC gene (190080). See also Couturier et al. (1991). Thus, cis-activation of cellular oncogenes seems to be responsible for malignant transformation of cervical epithelial cells in some cervical cancers.


▼ REFERENCES

  1. Couturier, J., Sastre-Garau, X., Schneider-Maunoury, S., Labib, A., Orth, G. Integration of papillomavirus DNA near myc genes in genital carcinomas and its consequences for proto-oncogene expression. J. Virol. 65: 4534-4538, 1991. [PubMed: 1649348, related citations] [Full Text]

  2. Durst, M., Croce, C. M., Gissmann, L., Schwarz, E., Huebner, K. Papilloma virus sequences integrate near cellular oncogenes in some cervical carcinomas. Proc. Nat. Acad. Sci. 84: 1070-1074, 1987. [PubMed: 3029760, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 2/14/1992
Edit History:
psherman : 11/23/1998
psherman : 11/20/1998
dkim : 7/24/1998
carol : 11/12/1993
supermim : 3/16/1992
carol : 2/14/1992

167959

HUMAN PAPILLOMAVIRUS TYPE 18 INTEGRATION SITE 1; HPV18I1


Alternative titles; symbols

PAPILLOMAVIRUS TYPE 18 INTEGRATION SITE 1


HGNC Approved Gene Symbol: HPV18I1

Cytogenetic location: 8q24     Genomic coordinates (GRCh38): 8:116,700,001-145,138,636


TEXT

In 2 cervical carcinoma cell lines, HeLa and C4-I, Durst et al. (1987) found that HPV18 DNA was integrated into chromosome 8, 5-prime to the MYC gene (190080). See also Couturier et al. (1991). Thus, cis-activation of cellular oncogenes seems to be responsible for malignant transformation of cervical epithelial cells in some cervical cancers.


REFERENCES

  1. Couturier, J., Sastre-Garau, X., Schneider-Maunoury, S., Labib, A., Orth, G. Integration of papillomavirus DNA near myc genes in genital carcinomas and its consequences for proto-oncogene expression. J. Virol. 65: 4534-4538, 1991. [PubMed: 1649348] [Full Text: https://doi.org/10.1128/JVI.65.8.4534-4538.1991]

  2. Durst, M., Croce, C. M., Gissmann, L., Schwarz, E., Huebner, K. Papilloma virus sequences integrate near cellular oncogenes in some cervical carcinomas. Proc. Nat. Acad. Sci. 84: 1070-1074, 1987. [PubMed: 3029760] [Full Text: https://doi.org/10.1073/pnas.84.4.1070]


Creation Date:
Victor A. McKusick : 2/14/1992

Edit History:
psherman : 11/23/1998
psherman : 11/20/1998
dkim : 7/24/1998
carol : 11/12/1993
supermim : 3/16/1992
carol : 2/14/1992



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 4, 2024