HGNC Approved Gene Symbol: RPS18
Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,272,075-33,276,511 (from NCBI)
In a search for new genes preferentially expressed in cytotrophoblasts of first-trimester human placenta, Chassin et al. (1993) made a subtracted cDNA library and found clones with an open reading frame showing a sequence that predicted a protein with 100% amino acid homology to the mouse ke3 gene product. The Ke3 gene in the mouse is located in the major histocompatibility complex. The deduced RPS18 protein has 152 amino acids (SWISS-PROT P62269).
In their GenBank submission (X69150), Chassin et al. (1993) noted that the RPS18 gene maps to chromosome 6p21.3. Kenmochi et al. (1998) mapped the RPS18 gene to 6p using somatic cell hybrid and radiation hybrid mapping analyses.
Chassin, D., Bellet, D., Koman, A. The human homolog of ribosomal protein S18. Nucleic Acids Res. 21: 745 only, 1993. [PubMed: 8441687] [Full Text: https://doi.org/10.1093/nar/21.3.745]
Kenmochi, N., Kawaguchi, T., Rozen, S., Davis, E., Goodman, N., Hudson, T. J., Tanaka, T., Page, D. C. A map of 75 human ribosomal protein genes. Genome Res. 8: 509-523, 1998. [PubMed: 9582194] [Full Text: https://doi.org/10.1101/gr.8.5.509]