A surface antigen termed S6 was identified by Cicurel and Croce (1977). S6 is coded by chromosome 7; regional assignment has not been done. (In somatic cell hybrids, Knowles et al. (1977) also demonstrated a cell surface antigen that segregated with chromosome 7; this was termed S7 as the sequential antigen identified. Knowles et al. (1978) concluded that the chromosome 7 surface antigens are determined by gene(s) on the short arm. Knowles (1981) identified S7 with the receptor for epidermal growth factor (131550) which was already known to be on chromosome 7, specifically 7p12-7p22.) (Much confusion exists in the numbering system of the surface antigens coded by chromosome 7. The report of the Human Gene Mapping Conference (HGM6) in Oslo in 1981 (p. 238) termed the antigen identical to EGFR as S6; it was earlier called SA7-1. The separate antigen coded by chromosome 7 and previously designated SA7-2 was termed S7.)
Aden, D. P., Knowles, B. B. Cell surface antigens coded for by the human chromosome 7. Immunogenetics 3: 209-221, 1976.
Cicurel, L., Croce, C. M. Somatic cell hybrids between mouse peritoneal macrophages and SV40-transformed human cells. III. Identification of surface antigens coded for by human chromosomes 7 and 17. J. Immun. 118: 1951-1956, 1977. [PubMed: 193988]
Knowles, B. B., Mausner, R., Aden, D. P. Preliminary characterization of human cell surface molecules controlled by human chromosomes 6 and 7. Cytogenet. Cell Genet. 22: 250-254, 1978. [PubMed: 752483] [Full Text: https://doi.org/10.1159/000130948]
Knowles, B. B., Solter, D., Trinchieri, G., Maloney, K. M., Ford, S. R., Aden, D. P. Complement-mediated antiserum cytotoxic reaction to human chromosome 7 coded antigen(s): immunoselection of rearranged human chromosome 7 in human-mouse somatic cell hybrids. J. Exp. Med. 145: 314-326, 1977. [PubMed: 188970] [Full Text: https://doi.org/10.1084/jem.145.2.314]
Knowles, B. B. Personal Communication. Philadelphia, Pa. 6/3/1981.