Entry - *186860 - T-CELL LEUKEMIA/LYMPHOMA 4; TCL4 - OMIM

 
 
* 186860

T-CELL LEUKEMIA/LYMPHOMA 4; TCL4


Cytogenetic location: 2q34     Genomic coordinates (GRCh38): 2:208,200,001-214,500,000


Gene-Phenotype Relationships
Location Phenotype Phenotype
MIM number 		Inheritance Phenotype
mapping key
2q34 Leukemia/lymphoma, T-cell 186860 2

▼ TEXT

Finger et al. (1988) studied an unusual MYC rearrangement in a human leukemic T-cell line derived from a patient with Sezary syndrome whose serum contained antibodies to human T-cell leukemia virus type 1 (HTLV-1). Translocation between chromosomes 2 and 8 was present in the cell line. They found that a locus derived from chromosome region 2q34 was attached to the 3-prime end of 1 MYC allele. The t(2;8) rearrangement in this cell line resulted in expression of a fused transcript encompassing the MYC gene and a locus designated TCL4 (T-cell leukemia/lymphoma-4). Presumably, the rearrangement was involved in the pathogenesis of the malignancy.


▼ REFERENCES

  1. Finger, L. R., Huebner, K., Cannizzaro, L. A., McLeod, K., Nowell, P. C., Croce, C. M. Chromosomal translocation in T-cell leukemia line HUT 78 results in a MYC fusion transcript. Proc. Nat. Acad. Sci. 85: 9158-9162, 1988. [PubMed: 3194416, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 12/30/1988
Edit History:
carol : 04/09/1999
dkim : 7/16/1998
mimadm : 5/10/1995
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/27/1989
root : 1/3/1989
root : 12/30/1988

* 186860

T-CELL LEUKEMIA/LYMPHOMA 4; TCL4


Cytogenetic location: 2q34     Genomic coordinates (GRCh38): 2:208,200,001-214,500,000


Gene-Phenotype Relationships

Location Phenotype Phenotype
MIM number 		Inheritance Phenotype
mapping key
2q34 Leukemia/lymphoma, T-cell 186860 2

TEXT

Finger et al. (1988) studied an unusual MYC rearrangement in a human leukemic T-cell line derived from a patient with Sezary syndrome whose serum contained antibodies to human T-cell leukemia virus type 1 (HTLV-1). Translocation between chromosomes 2 and 8 was present in the cell line. They found that a locus derived from chromosome region 2q34 was attached to the 3-prime end of 1 MYC allele. The t(2;8) rearrangement in this cell line resulted in expression of a fused transcript encompassing the MYC gene and a locus designated TCL4 (T-cell leukemia/lymphoma-4). Presumably, the rearrangement was involved in the pathogenesis of the malignancy.


REFERENCES

  1. Finger, L. R., Huebner, K., Cannizzaro, L. A., McLeod, K., Nowell, P. C., Croce, C. M. Chromosomal translocation in T-cell leukemia line HUT 78 results in a MYC fusion transcript. Proc. Nat. Acad. Sci. 85: 9158-9162, 1988. [PubMed: 3194416] [Full Text: https://doi.org/10.1073/pnas.85.23.9158]


Creation Date:
Victor A. McKusick : 12/30/1988

Edit History:
carol : 04/09/1999
dkim : 7/16/1998
mimadm : 5/10/1995
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/27/1989
root : 1/3/1989
root : 12/30/1988



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 17, 2024