Entry - *189920 - tRNA LEUCINE (ANTICODON TAG) 1-1; TRL-TAG1-1 - OMIM

 
 
* 189920

tRNA LEUCINE (ANTICODON TAG) 1-1; TRL-TAG1-1


Alternative titles; symbols

tRNA-LEU (ANTICODON TAG) 1-1
TRANSFER RNA LEUCINE (ANTICODON TAG) 1-1
TRANSFER RNA LEUCINE 2; TRNAL2
tRNA LEUCINE 2; TRL2


HGNC Approved Gene Symbol: TRL-TAG1-1

Cytogenetic location: 17p13.1     Genomic coordinates (GRCh38): 17:8,120,314-8,120,395 (from NCBI)


TEXT

▼ Mapping

Morrison et al. (1988, 1989) investigated a cluster of tRNA genes, including TRL2. In situ hybridization with biotin labeling permitted localization to 17pter-p12. By in situ hybridization, Morrison et al. (1989) showed that the corresponding gene is located on the short arm of chromosome 19 in the orangutan, providing further support for homology between chromosome 19 in the higher primates and chromosome 17 in man. In the gorilla the cluster was located on the long arm of chromosome 19. By means of a somatic cell hybrid mapping panel, Morrison et al. (1991) confirmed and refined the assignment to 17p13.100-p13.105. Morrison et al. (1991) reported that tRNA(arg) (TRR1; 610406) is in the same cluster and that a tRNA(gly) (TRG2; 610407) gene is within 4 kb of the tRNA(arg) gene of the cluster on genomic DNA. It was independently localized to the same chromosome position.


▼ Gene Structure

Bourn et al. (1994) determined that the first 4 genes of the cluster, TRL2, TRK1 (189918), TRQ1 (189919), and TRR1 are separated from the TRG2 gene by a CpG island, and they are copied at least 2 and possibly 3 times within chromosome 17p13.1. All 5 genes are further copied in other arrangements within the same small chromosomal region; the TRL2 gene is copied a minimum of 10 times.


▼ REFERENCES

  1. Bourn, D., Carr, T., Livingstone, D., McLaren, A., Goddard, J. P. An intron-containing tRNA(Arg) gene within a large cluster of human tRNA genes. DNA Seq. 5: 83-92, 1994. [PubMed: 7703509, related citations] [Full Text]

  2. Morrison, N., Goddard, J., Connor, J. M., Boyd, E. Chromosomal assignment of a tRNA gene cluster (tRNA-Leu, tRNA-Gln, tRNA-Lys) to 17p12-pter. (Abstract) Clinical Genetics Society, Aberdeen, Scotland 1988.

  3. Morrison, N., Goddard, J. P., Bourn, D., Connor, J. M., Boyd, E. Chromosomal assignment to 17p12-17pter of a tRNA gene cluster (a leucine tRNA, a glutamine tRNA, and a lysine tRNA). (Abstract) Cytogenet. Cell Genet. 51: 1048 only, 1989.

  4. Morrison, N., Goddard, J. P., Ledbetter, D. H., Boyd, E., Bourn, D., Connor, J. M. Chromosomal assignment of a large tRNA gene cluster (tRNA-leu, tRNA-gln, tRNA-lys, tRNA-arg, tRNA-gly) to 17p13.1. Hum. Genet. 87: 226-230, 1991. [PubMed: 2066114, related citations] [Full Text]


Contributors:
Patricia A. Hartz - updated : 9/14/2006
Creation Date:
Victor A. McKusick : 9/27/1988
Edit History:
mgross : 01/08/2021
mgross : 11/30/2020
carol : 10/14/2016
alopez : 04/04/2012
carol : 9/1/2009
wwang : 9/14/2006
alopez : 7/26/1999
dkim : 7/16/1998
mimadm : 4/7/1994
warfield : 3/7/1994
supermim : 3/16/1992
carol : 12/2/1991
supermim : 3/20/1990
carol : 3/7/1990

* 189920

tRNA LEUCINE (ANTICODON TAG) 1-1; TRL-TAG1-1


Alternative titles; symbols

tRNA-LEU (ANTICODON TAG) 1-1
TRANSFER RNA LEUCINE (ANTICODON TAG) 1-1
TRANSFER RNA LEUCINE 2; TRNAL2
tRNA LEUCINE 2; TRL2


HGNC Approved Gene Symbol: TRL-TAG1-1

Cytogenetic location: 17p13.1     Genomic coordinates (GRCh38): 17:8,120,314-8,120,395 (from NCBI)


TEXT

Mapping

Morrison et al. (1988, 1989) investigated a cluster of tRNA genes, including TRL2. In situ hybridization with biotin labeling permitted localization to 17pter-p12. By in situ hybridization, Morrison et al. (1989) showed that the corresponding gene is located on the short arm of chromosome 19 in the orangutan, providing further support for homology between chromosome 19 in the higher primates and chromosome 17 in man. In the gorilla the cluster was located on the long arm of chromosome 19. By means of a somatic cell hybrid mapping panel, Morrison et al. (1991) confirmed and refined the assignment to 17p13.100-p13.105. Morrison et al. (1991) reported that tRNA(arg) (TRR1; 610406) is in the same cluster and that a tRNA(gly) (TRG2; 610407) gene is within 4 kb of the tRNA(arg) gene of the cluster on genomic DNA. It was independently localized to the same chromosome position.


Gene Structure

Bourn et al. (1994) determined that the first 4 genes of the cluster, TRL2, TRK1 (189918), TRQ1 (189919), and TRR1 are separated from the TRG2 gene by a CpG island, and they are copied at least 2 and possibly 3 times within chromosome 17p13.1. All 5 genes are further copied in other arrangements within the same small chromosomal region; the TRL2 gene is copied a minimum of 10 times.


REFERENCES

  1. Bourn, D., Carr, T., Livingstone, D., McLaren, A., Goddard, J. P. An intron-containing tRNA(Arg) gene within a large cluster of human tRNA genes. DNA Seq. 5: 83-92, 1994. [PubMed: 7703509] [Full Text: https://doi.org/10.3109/10425179409039709]

  2. Morrison, N., Goddard, J., Connor, J. M., Boyd, E. Chromosomal assignment of a tRNA gene cluster (tRNA-Leu, tRNA-Gln, tRNA-Lys) to 17p12-pter. (Abstract) Clinical Genetics Society, Aberdeen, Scotland 1988.

  3. Morrison, N., Goddard, J. P., Bourn, D., Connor, J. M., Boyd, E. Chromosomal assignment to 17p12-17pter of a tRNA gene cluster (a leucine tRNA, a glutamine tRNA, and a lysine tRNA). (Abstract) Cytogenet. Cell Genet. 51: 1048 only, 1989.

  4. Morrison, N., Goddard, J. P., Ledbetter, D. H., Boyd, E., Bourn, D., Connor, J. M. Chromosomal assignment of a large tRNA gene cluster (tRNA-leu, tRNA-gln, tRNA-lys, tRNA-arg, tRNA-gly) to 17p13.1. Hum. Genet. 87: 226-230, 1991. [PubMed: 2066114] [Full Text: https://doi.org/10.1007/BF00204190]


Contributors:
Patricia A. Hartz - updated : 9/14/2006

Creation Date:
Victor A. McKusick : 9/27/1988

Edit History:
mgross : 01/08/2021
mgross : 11/30/2020
carol : 10/14/2016
alopez : 04/04/2012
carol : 9/1/2009
wwang : 9/14/2006
alopez : 7/26/1999
dkim : 7/16/1998
mimadm : 4/7/1994
warfield : 3/7/1994
supermim : 3/16/1992
carol : 12/2/1991
supermim : 3/20/1990
carol : 3/7/1990



NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 5, 2024