Entry - *191161 - TUMOR NECROSIS FACTOR-ALPHA-INDUCED PROTEIN 1; TNFAIP1 - OMIM

 
 
* 191161

TUMOR NECROSIS FACTOR-ALPHA-INDUCED PROTEIN 1; TNFAIP1


Alternative titles; symbols

TUMOR NECROSIS FACTOR-ALPHA-INDUCED PROTEIN, ENDOTHELIAL


HGNC Approved Gene Symbol: TNFAIP1

Cytogenetic location: 17q11.2     Genomic coordinates (GRCh38): 17:28,335,761-28,347,009 (from NCBI)


TEXT

▼ Cloning and Expression

Wolf et al. (1992) characterized a novel cDNA by differential screening of a tumor necrosis factor-alpha (TNFA; 191160)-stimulated umbilical vein endothelial cell library. The protein product is involved in the primary response of the endothelium to TNF. The 3.5-kb transcript was found to be expressed in a developmentally regulated, tissue-specific manner.


▼ Mapping

Wolf et al. (1992) mapped the TNFAIP1 gene to chromosome 17q22-q23 by in situ hybridization.


▼ REFERENCES

  1. Wolf, F. W., Marks, R. M., Sarma, V., Byers, M. G., Katz, R. W., Shows, T. B., Dixit, V. M. Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene. J. Biol. Chem. 267: 1317-1326, 1992. [PubMed: 1370465, related citations]


Creation Date:
Victor A. McKusick : 1/13/1993
Edit History:
carol : 01/02/2014
carol : 3/17/1999
psherman : 11/19/1998
carol : 1/13/1993

* 191161

TUMOR NECROSIS FACTOR-ALPHA-INDUCED PROTEIN 1; TNFAIP1


Alternative titles; symbols

TUMOR NECROSIS FACTOR-ALPHA-INDUCED PROTEIN, ENDOTHELIAL


HGNC Approved Gene Symbol: TNFAIP1

Cytogenetic location: 17q11.2     Genomic coordinates (GRCh38): 17:28,335,761-28,347,009 (from NCBI)


TEXT

Cloning and Expression

Wolf et al. (1992) characterized a novel cDNA by differential screening of a tumor necrosis factor-alpha (TNFA; 191160)-stimulated umbilical vein endothelial cell library. The protein product is involved in the primary response of the endothelium to TNF. The 3.5-kb transcript was found to be expressed in a developmentally regulated, tissue-specific manner.


Mapping

Wolf et al. (1992) mapped the TNFAIP1 gene to chromosome 17q22-q23 by in situ hybridization.


REFERENCES

  1. Wolf, F. W., Marks, R. M., Sarma, V., Byers, M. G., Katz, R. W., Shows, T. B., Dixit, V. M. Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene. J. Biol. Chem. 267: 1317-1326, 1992. [PubMed: 1370465]


Creation Date:
Victor A. McKusick : 1/13/1993

Edit History:
carol : 01/02/2014
carol : 3/17/1999
psherman : 11/19/1998
carol : 1/13/1993



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 20, 2024