Alternative titles; symbols
HGNC Approved Gene Symbol: TYRL
Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:43,400,001-48,800,000
As indicated in 606933, in the mapping of the tyrosinase locus with a cDNA probe in somatic cell and in situ hybridization, Barton et al. (1988) identified a second site of tyrosinase-related sequences in the region 11p11.2-cen. The primary locus is on 11q14-q21. The functional significance of the second sequence is unknown. Giebel et al. (1991) demonstrated that whereas the tyrosinase gene contains 5 exons, the tyrosinase-like, or tyrosinase-related, 'gene' contains only exons 4 and 5 plus adjacent noncoding regions. The tyrosinase-related segment was found in all human ethnic groups analyzed, and the noncoding nucleotide sequences shared by the 11q tyrosinase gene and the 11p tyrosinase-related segment differed by only 2.6%. This suggested to Giebel et al. (1991) that the 11p segment was duplicated approximately 24 million years ago.
Barton, D. E., Kwon, B. S., Francke, U. Human tyrosinase gene, mapped to chromosome 11 (q14-q21), defines second region of homology with mouse chromosome 7. Genomics 3: 17-24, 1988. [PubMed: 3146546] [Full Text: https://doi.org/10.1016/0888-7543(88)90153-x]
Giebel, L. B., Strunk, K. M., Spritz, R. A. Organization and nucleotide sequences of the human tyrosinase gene and a truncated tyrosinase-related segment. Genomics 9: 435-445, 1991. [PubMed: 1903356] [Full Text: https://doi.org/10.1016/0888-7543(91)90409-8]