* 191325

UBIQUITIN-LIKE MODIFIER ACTIVATING ENZYME 7; UBA7


Alternative titles; symbols

UBIQUITIN-ACTIVATING ENZYME 7; UBE7
UBIQUITIN-ACTIVATING ENZYME E1-LIKE; UBE1L


HGNC Approved Gene Symbol: UBA7

Cytogenetic location: 3p21.31     Genomic coordinates (GRCh38): 3:49,805,209-49,813,953 (from NCBI)


TEXT

Cloning and Expression

Because it is almost always deleted in lung tumors of the small cell type (SCLC; 182280), the 3p21 region is thought to be the site of a lung tumor suppressor gene. Carritt et al. (1992) identified a gene located in this region that is expressed in a variety of tissues, including normal lung, but whose expression in a large series of lung cancer cell lines, both SCLC and non-SCLC, was undetectable by RNA Northern blot analysis.

Kok et al. (1993) reported the sequence of this gene, which they called D8, and showed that it has significant homology to the genes encoding the ubiquitin-activating enzymes (see UBE1; 314370) of 3 species, including humans. The D8 cDNA encodes a deduced 1,011 amino acid protein. Kok et al. (1993) concluded that this gene may represent a second, autosomal member of the ubiquitin-activating gene family, and may play a role in the ubiquitin conjugation pathway.


Mapping

Carritt et al. (1992) identified the UBE1L gene on chromosome 3p21.


REFERENCES

  1. Carritt, B., Kok, K., van den Berg, A., Osinga, J., Pilz, A., Hofstra, R. M. W., Davis, M. B., van der Veen, A. Y., Rabbitts, P. H., Gulati, K., Buys, C. H. C. M. A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer. Cancer Res. 52: 1536-1541, 1992. [PubMed: 1311632, related citations]

  2. Kok, K., Hofstra, R., Pilz, A., van den Berg, A., Terpstra, P., Buys, C. H. C. M., Carritt, B. A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. Proc. Nat. Acad. Sci. 90: 6071-6075, 1993. [PubMed: 8327486, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 7/13/1993
mgross : 04/18/2022
carol : 01/02/2014
psherman : 8/3/1998
carol : 7/13/1993

* 191325

UBIQUITIN-LIKE MODIFIER ACTIVATING ENZYME 7; UBA7


Alternative titles; symbols

UBIQUITIN-ACTIVATING ENZYME 7; UBE7
UBIQUITIN-ACTIVATING ENZYME E1-LIKE; UBE1L


HGNC Approved Gene Symbol: UBA7

Cytogenetic location: 3p21.31     Genomic coordinates (GRCh38): 3:49,805,209-49,813,953 (from NCBI)


TEXT

Cloning and Expression

Because it is almost always deleted in lung tumors of the small cell type (SCLC; 182280), the 3p21 region is thought to be the site of a lung tumor suppressor gene. Carritt et al. (1992) identified a gene located in this region that is expressed in a variety of tissues, including normal lung, but whose expression in a large series of lung cancer cell lines, both SCLC and non-SCLC, was undetectable by RNA Northern blot analysis.

Kok et al. (1993) reported the sequence of this gene, which they called D8, and showed that it has significant homology to the genes encoding the ubiquitin-activating enzymes (see UBE1; 314370) of 3 species, including humans. The D8 cDNA encodes a deduced 1,011 amino acid protein. Kok et al. (1993) concluded that this gene may represent a second, autosomal member of the ubiquitin-activating gene family, and may play a role in the ubiquitin conjugation pathway.


Mapping

Carritt et al. (1992) identified the UBE1L gene on chromosome 3p21.


REFERENCES

  1. Carritt, B., Kok, K., van den Berg, A., Osinga, J., Pilz, A., Hofstra, R. M. W., Davis, M. B., van der Veen, A. Y., Rabbitts, P. H., Gulati, K., Buys, C. H. C. M. A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer. Cancer Res. 52: 1536-1541, 1992. [PubMed: 1311632]

  2. Kok, K., Hofstra, R., Pilz, A., van den Berg, A., Terpstra, P., Buys, C. H. C. M., Carritt, B. A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. Proc. Nat. Acad. Sci. 90: 6071-6075, 1993. [PubMed: 8327486] [Full Text: https://doi.org/10.1073/pnas.90.13.6071]


Creation Date:
Victor A. McKusick : 7/13/1993

Edit History:
mgross : 04/18/2022
carol : 01/02/2014
psherman : 8/3/1998
carol : 7/13/1993