Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF182
Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:47,974,851-48,003,989 (from NCBI)
Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (603971) for general information on ZNFs.
Knight et al. (1994) localized the ZNF21 gene to chromosome Xp22.11-p11.23 in a cluster of zinc finger protein genes. The ZNF21 gene had previously been mapped to Xp by Huebner et al. (1991). Stoddart et al. (1999) mapped the ZNF21 gene to Xp11.3 by inclusion within a YAC contig.
Huebner, K., Druck, T., Croce, C. M., Thiesen, H. J. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Am. J. Hum. Genet. 48: 726-740, 1991. [PubMed: 2014798]
Knight, J. C., Grimaldi, G., Thiesen, H.-J., Bech-Hansen, N. T., Fletcher, C. D. M., Coleman, M. P. Clustered organization of Kruppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1. Genomics 21: 180-187, 1994. [PubMed: 8088786] [Full Text: https://doi.org/10.1006/geno.1994.1240]
Stoddart, K. L., Jermak, C., Nagaraja, R., Schlessinger, D., Bech-Hansen, N. T. Physical map covering a 2 Mb region in human Xp11.3 distal to DX6849. Gene 227: 111-116, 1999. [PubMed: 9931462] [Full Text: https://doi.org/10.1016/s0378-1119(98)00564-2]