Alternative titles; symbols
HGNC Approved Gene Symbol: ADCY4
Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,318,359-24,335,071 (from NCBI)
ADCY4 belongs to the adenylate cyclase (EC 4.6.1.1) family of enzymes responsible for the synthesis of cAMP (Ludwig and Seuwen, 2002).
Wong et al. (2000) identified the presence of adenylyl cyclases 2 (103071), 3 (600291), and 4 in olfactory cilia.
By database analysis and PCR of a human trabecular bone cell cDNA library, Ludwig and Seuwen (2002) identified full-length ADCY4. The deduced protein contains 1,077 amino acids. Semiquantitative RT-PCR detected ubiquitous expression of ADCY at moderate levels.
Ludwig and Seuwen (2002) determined that the ADCY4 gene contains 25 exons and spans 16.3 kb.
By Southern blot analysis of somatic cell hybrid DNAs, Gaudin et al. (1994) mapped the ADCY4 gene to chromosome 14. By fluorescence in situ hybridization, Edelhoff et al. (1995) mapped the ADCY4 gene to human chromosome 14q11.2 and the mouse homolog to chromosome 14 in the D3 region.
Edelhoff, S., Villacres, E. C., Storm, D. R., Disteche, C. M. Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse. Mammalian Genome 6: 111-113, 1995. [PubMed: 7766992] [Full Text: https://doi.org/10.1007/BF00303253]
Gaudin, C., Homcy, C. J., Ishikawa, Y. Mammalian adenylyl cyclase family members are randomly located on different chromosomes. Hum. Genet. 94: 527-529, 1994. [PubMed: 7959689] [Full Text: https://doi.org/10.1007/BF00211020]
Ludwig, M.-G., Seuwen, K. Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. J. Recept. Signal Transduct. Res. 22: 79-110, 2002. [PubMed: 12503609] [Full Text: https://doi.org/10.1081/rrs-120014589]
Wong, S. T., Trinh, K., Hacker, B., Chan, G. C. K., Lowe, G., Gaggar, A., Xia, Z., Gold, G. H., Storm, D. R. Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron 27: 487-497, 2000. [PubMed: 11055432] [Full Text: https://doi.org/10.1016/s0896-6273(00)00060-x]