Alternative titles; symbols
HGNC Approved Gene Symbol: ALDH3B1
Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:68,008,547-68,029,276 (from NCBI)
The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Hsu et al. (1994) reported the cloning and sequencing of a cDNA encoding a new human ALDH, designated ALDH7. Degenerate oligodeoxyribonucleotides derived from conserved regions of known ALDH cDNAs amplified a 408-bp product from human kidney total RNA by the reverse transcription-PCR procedure. This PCR product was subcloned, selected, and used as a probe to screen a human kidney cDNA library. The full-length human kidney cDNA of ALDH7 is 2,791 bp long and contains an open reading frame encoding 468 amino acids. The deduced sequence of ALDH7 was longer than that of human stomach ALDH3 (100660) by 15 amino acids at the C terminus. The degree of identity between the 2 isozymes was 52% with a positional alignment of 453 amino acids. Northern blot analysis demonstrated that lung is another major tissue expressing ALDH7.
Hsu et al. (1997) determined the structure of the ALDH7 and ALDH8 (601917) genes. The ALDH7 gene spans about 20 kb of genomic DNA and is composed of 9 coding exons. The ALDH8 gene is over 10 kb in length and consists of at least 10 exons. The ALDH8 gene contains an in-frame stop codon at the seventeenth codon position from the first initiator Met. The coding region of the ALDH7 gene shows about 86% nucleotide identity with the corresponding region of the ALDH8 gene. The numbers and positions of the introns of the 2 genes are conserved, suggesting that gene duplication is involved in the expansion of the ALDH gene family. The human ALDH7 and ALDH8 genes have a close evolutionary relationship with human ALDH3.
Hsu et al. (1997) stated that the ALDH7 gene maps to chromosome 11q13.
Hsu, L. C., Chang, W.-C., Yoshida, A. Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family. Gene 151: 285-289, 1994. [PubMed: 7828891] [Full Text: https://doi.org/10.1016/0378-1119(94)90672-6]
Hsu, L. C., Chang, W.-C., Yoshida, A. Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison. Gene 189: 89-94, 1997. [PubMed: 9161417] [Full Text: https://doi.org/10.1016/s0378-1119(96)00839-6]