Entry - *600719 - NITRIC OXIDE SYNTHASE 2B; NOS2B - OMIM

 
 
* 600719

NITRIC OXIDE SYNTHASE 2B; NOS2B


HGNC Approved Gene Symbol: NOS2P2

Cytogenetic location: 17p11.2     Genomic coordinates (GRCh38): 17:18,497,090-18,503,285 (from NCBI)


TEXT

▼ Cloning and Expression

Using a bovine NOS II-related cDNA to screen 2 human genomic libraries, Bloch et al. (1995) isolated clones containing 3 independent genes. One clone encoded the previously identified gene NOS2 (163730), which they called NOS2A. The other 2 genes specified amino acids homologous, but not identical, to those specified by the NOS2A gene; these were designated NOS2B and NOS2C (NOS2P1; 600720).


▼ Mapping

By Southern blot hybridization, Bloch et al. (1995) demonstrated that the NOS2A, NOS2B, and NOS2C genes are located on chromosome 17 between bands 17p13.1 and 17q25.


▼ REFERENCES

  1. Bloch, K. D., Wolfram, J. R., Brown, D. M., Roberts, J. D., Jr., Zapol, D. G., Lepore, J. J., Filippov, G., Thomas, J. E., Jacob, H. J., Bloch, D. B. Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17. Genomics 27: 526-530, 1995. [PubMed: 7558036, related citations] [Full Text]


Contributors:
Ada Hamosh - updated : 5/5/1999
Creation Date:
Victor A. McKusick : 8/11/1995
Edit History:
mgross : 10/12/2020
alopez : 05/09/2014
terry : 6/6/2012
carol : 11/5/2004
alopez : 5/7/1999
terry : 5/5/1999
mark : 8/11/1995

* 600719

NITRIC OXIDE SYNTHASE 2B; NOS2B


HGNC Approved Gene Symbol: NOS2P2

Cytogenetic location: 17p11.2     Genomic coordinates (GRCh38): 17:18,497,090-18,503,285 (from NCBI)


TEXT

Cloning and Expression

Using a bovine NOS II-related cDNA to screen 2 human genomic libraries, Bloch et al. (1995) isolated clones containing 3 independent genes. One clone encoded the previously identified gene NOS2 (163730), which they called NOS2A. The other 2 genes specified amino acids homologous, but not identical, to those specified by the NOS2A gene; these were designated NOS2B and NOS2C (NOS2P1; 600720).


Mapping

By Southern blot hybridization, Bloch et al. (1995) demonstrated that the NOS2A, NOS2B, and NOS2C genes are located on chromosome 17 between bands 17p13.1 and 17q25.


REFERENCES

  1. Bloch, K. D., Wolfram, J. R., Brown, D. M., Roberts, J. D., Jr., Zapol, D. G., Lepore, J. J., Filippov, G., Thomas, J. E., Jacob, H. J., Bloch, D. B. Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17. Genomics 27: 526-530, 1995. [PubMed: 7558036] [Full Text: https://doi.org/10.1006/geno.1995.1086]


Contributors:
Ada Hamosh - updated : 5/5/1999

Creation Date:
Victor A. McKusick : 8/11/1995

Edit History:
mgross : 10/12/2020
alopez : 05/09/2014
terry : 6/6/2012
carol : 11/5/2004
alopez : 5/7/1999
terry : 5/5/1999
mark : 8/11/1995



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 20, 2024