Alternative titles; symbols
HGNC Approved Gene Symbol: NOS2P1
Cytogenetic location: 17p13.1-q25 Genomic coordinates (GRCh38): 17:6,500,001-83,257,441
NOS2P1 is a nontranscribed pseudogene located near the functional NOS2 gene (163730) on chromosome 17 (Park et al., 1997).
Using a bovine NOS II-related cDNA to screen 2 human genomic libraries, Bloch et al. (1995) isolated clones containing 3 independent genes. One clone encoded the previously identified gene, NOS2, which they called NOS2A. The other 2 genes specified amino acids homologous, but not identical, to those specified by the NOS2A gene; these were designated NOS2B (600719) and NOS2C.
Park et al. (1997) determined that NOS2C, which they called NOSII-2, is an unprocessed pseudogene that cannot produce a functional enzyme due to incomplete sequences and mutations relative to the functional NOS2 gene.
By Southern blot hybridization, Bloch et al. (1995) demonstrated that the NOS2A, NOS2B, and NOS2C genes are located on chromosome 17 between bands 17p13.1 and 17q25.
Using FISH, Park et al. (1997) mapped the NOS2P1 pseudogene to chromosome 17q11.2 near the functional NOS2 gene.
Bloch, K. D., Wolfram, J. R., Brown, D. M., Roberts, J. D., Jr., Zapol, D. G., Lepore, J. J., Filippov, G., Thomas, J. E., Jacob, H. J., Bloch, D. B. Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17. Genomics 27: 526-530, 1995. [PubMed: 7558036] [Full Text: https://doi.org/10.1006/geno.1995.1086]
Park, C.-S., Lee, H.-S., Lee, H.-Y., Krishna, G. An unprocessed pseudogene of inducible nitric oxide synthase in human. Nitric Oxide 1: 294-300, 1997. [PubMed: 9441901] [Full Text: https://doi.org/10.1006/niox.1997.0138]