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The human papillomavirus (HPV) E5 genes play an important role in the induction of proliferation of infected cells. Geisen et al. (1995) noted that these HPV E5 genomic regions are affected by the events leading to integration of genital HPVs. Following up on the description of 2 HPV18 E5-related, transcribed mouse sequences, Geisen et al. (1995) searched for human equivalents to these sequences. They isolated a clone with a 9.6-kb insert from a laryngeal carcinoma DNA library that strongly cross-hybridized with the 2 mouse sequences. Restriction and Southern blot analyses showed that the insert was a single-copy sequence without rearrangements or viral sequences. The E5-related region was transcribed and produced a 1.9-kb RNA band detected in the poly(A)+ RNA from different cell lines tested. The human gene was designated PE5L (for papillomavirus E5-like) by the authors.
By fluorescence in situ hybridization, Geisen et al. (1995) mapped the HPVC1 gene to 7p14-p13. They concluded that this gene belongs to an E5-like family of intracellular sequences and that it may constitute a target for HPV recombination.
Geisen, C., Delius, H., Lichter, P., Kahn, T. A transcribed human sequence related to the mouse HC1 and the human papillomavirus type 18 E5 genes is located at chromosome 7p13-14. Hum. Molec. Genet. 4: 1337-1345, 1995. [PubMed: 7581372] [Full Text: https://doi.org/10.1093/hmg/4.8.1337]