* 600926

PROTEIN-TYROSINE PHOSPHATASE, RECEPTOR-TYPE, EPSILON; PTPRE


HGNC Approved Gene Symbol: PTPRE

Cytogenetic location: 10q26.2     Genomic coordinates (GRCh38): 10:127,907,103-128,085,855 (from NCBI)


TEXT

For background information on protein-tyrosine phosphatases (PTPases), see 176884.


Cloning and Expression

By screening a human fetal liver cDNA library with a PTP-gamma (PTPRG; 176886) probe, Krueger et al. (1990) cloned a partial cDNA for PTPRE, which they called PTP-epsilon. The deduced protein has a transmembrane segment and a cytoplasmic region containing duplicated PTPase domains.

Elson et al. (1996) noted that 2 isoforms of PTP-epsilon, a transmembrane, receptor-type isoform and a shorter, cytoplasmic isoform, appear to arise through the use of alternative promoters and 5-prime exons.

High levels of PTPase-epsilon transcription were noted in mouse brain and testis by Yi et al. (1991).


Mapping

Van den Maagdenberg et al. (1995) isolated cosmids containing sequences for PTPRE and used these to map the gene to chromosome 10q26 by fluorescence in situ hybridization. Melhado et al. (1996) likewise showed that the PTPRE gene is located on 10q26 by isotopic in situ hybridization. Elson et al. (1996) also mapped the PTPRE gene to chromosome 10q26 by FISH.

Watanabe et al. (1995) mapped the mouse Ptpre gene to within the vicinity of the imprinted region in the distal part of chromosome 7. Elson et al. (1996) also mapped the mouse Ptpre gene to distal chromosome 7.


REFERENCES

  1. Elson, A., Kozak, C. A., Morton, C. C., Weremowicz, S., Leder, P. The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26. Genomics 31: 373-375, 1996. [PubMed: 8838320, related citations] [Full Text]

  2. Krueger, N. X., Streuli, M., Saito, H. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 9: 3241-3252, 1990. [PubMed: 2170109, related citations] [Full Text]

  3. Melhado, I. G., Anderson, L. L., Duncan, A. M. V., Jirik, F. R. The gene encoding protein-tyrosine phosphatase RPTP-epsilon (PTPRE) is assigned to human chromosome 10q26. Cytogenet. Cell Genet. 73: 168-170, 1996. [PubMed: 8697801, related citations] [Full Text]

  4. van den Maagdenberg, A. M. J. M., van den Hurk, H. H., Olde Weghuis, D., Wieringa, B., Geurts van Kessel, A., Hendriks, W. J. A. J. Assignment of the human protein tyrosine phosphatase epsilon (PTPRE) gene to chromosome 10q26 by fluorescence in situ hybridization. Genomics 30: 128-129, 1995. [PubMed: 8595895, related citations] [Full Text]

  5. Watanabe, T., Mukouyama, Y., Rhodes, M., Thomas, M., Kume, T., Oishi, M. Chromosomal location of murine protein tyrosine phosphatase (Ptprj and Ptpre) genes. Genomics 29: 793-795, 1995. [PubMed: 8575779, related citations] [Full Text]

  6. Yi, T., Cleveland, J. L., Ihle, J. N. Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood 78: 2222-2228, 1991. [PubMed: 1932742, related citations]


Contributors:
Patricia A. Hartz - updated : 10/29/2009
Creation Date:
Alan F. Scott : 11/7/1995
mgross : 11/06/2009
terry : 10/29/2009
dkim : 7/23/1998
dholmes : 4/8/1998
terry : 11/12/1996
terry : 4/17/1996
mark : 3/20/1996
mark : 3/20/1996
mark : 3/20/1996
terry : 3/11/1996
terry : 11/7/1995

* 600926

PROTEIN-TYROSINE PHOSPHATASE, RECEPTOR-TYPE, EPSILON; PTPRE


HGNC Approved Gene Symbol: PTPRE

Cytogenetic location: 10q26.2     Genomic coordinates (GRCh38): 10:127,907,103-128,085,855 (from NCBI)


TEXT

For background information on protein-tyrosine phosphatases (PTPases), see 176884.


Cloning and Expression

By screening a human fetal liver cDNA library with a PTP-gamma (PTPRG; 176886) probe, Krueger et al. (1990) cloned a partial cDNA for PTPRE, which they called PTP-epsilon. The deduced protein has a transmembrane segment and a cytoplasmic region containing duplicated PTPase domains.

Elson et al. (1996) noted that 2 isoforms of PTP-epsilon, a transmembrane, receptor-type isoform and a shorter, cytoplasmic isoform, appear to arise through the use of alternative promoters and 5-prime exons.

High levels of PTPase-epsilon transcription were noted in mouse brain and testis by Yi et al. (1991).


Mapping

Van den Maagdenberg et al. (1995) isolated cosmids containing sequences for PTPRE and used these to map the gene to chromosome 10q26 by fluorescence in situ hybridization. Melhado et al. (1996) likewise showed that the PTPRE gene is located on 10q26 by isotopic in situ hybridization. Elson et al. (1996) also mapped the PTPRE gene to chromosome 10q26 by FISH.

Watanabe et al. (1995) mapped the mouse Ptpre gene to within the vicinity of the imprinted region in the distal part of chromosome 7. Elson et al. (1996) also mapped the mouse Ptpre gene to distal chromosome 7.


REFERENCES

  1. Elson, A., Kozak, C. A., Morton, C. C., Weremowicz, S., Leder, P. The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26. Genomics 31: 373-375, 1996. [PubMed: 8838320] [Full Text: https://doi.org/10.1006/geno.1996.0061]

  2. Krueger, N. X., Streuli, M., Saito, H. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 9: 3241-3252, 1990. [PubMed: 2170109] [Full Text: https://doi.org/10.1002/j.1460-2075.1990.tb07523.x]

  3. Melhado, I. G., Anderson, L. L., Duncan, A. M. V., Jirik, F. R. The gene encoding protein-tyrosine phosphatase RPTP-epsilon (PTPRE) is assigned to human chromosome 10q26. Cytogenet. Cell Genet. 73: 168-170, 1996. [PubMed: 8697801] [Full Text: https://doi.org/10.1159/000134332]

  4. van den Maagdenberg, A. M. J. M., van den Hurk, H. H., Olde Weghuis, D., Wieringa, B., Geurts van Kessel, A., Hendriks, W. J. A. J. Assignment of the human protein tyrosine phosphatase epsilon (PTPRE) gene to chromosome 10q26 by fluorescence in situ hybridization. Genomics 30: 128-129, 1995. [PubMed: 8595895] [Full Text: https://doi.org/10.1006/geno.1995.0026]

  5. Watanabe, T., Mukouyama, Y., Rhodes, M., Thomas, M., Kume, T., Oishi, M. Chromosomal location of murine protein tyrosine phosphatase (Ptprj and Ptpre) genes. Genomics 29: 793-795, 1995. [PubMed: 8575779] [Full Text: https://doi.org/10.1006/geno.1995.9932]

  6. Yi, T., Cleveland, J. L., Ihle, J. N. Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood 78: 2222-2228, 1991. [PubMed: 1932742]


Contributors:
Patricia A. Hartz - updated : 10/29/2009

Creation Date:
Alan F. Scott : 11/7/1995

Edit History:
mgross : 11/06/2009
terry : 10/29/2009
dkim : 7/23/1998
dholmes : 4/8/1998
terry : 11/12/1996
terry : 4/17/1996
mark : 3/20/1996
mark : 3/20/1996
mark : 3/20/1996
terry : 3/11/1996
terry : 11/7/1995