Alternative titles; symbols
HGNC Approved Gene Symbol: HTR6
Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,664,875-19,680,966 (from NCBI)
The serotonin 5-HT-6 receptor is a member of the G protein-coupled receptor superfamily and stimulates adenylyl cyclase via G(s) coupling (summary by Kohen et al., 1996).
Monsma et al. (1989) cloned the rat 5-HT-6 receptor. Northern blot analysis demonstrated high expression in brain. Ward et al. (1995) found the rat serotonin subtype 6 receptor message in serotonin projection fields, rather than in regions of serotonin-containing cell bodies, suggesting that the receptor is mainly postsynaptic. Ward et al. (1995) stated that the 5-HT6 receptor had been shown to share high affinity for many therapeutically important antidepressant and antipsychotic drugs, particularly the atypical antipsychotics such as clozapine.
Kohen et al. (1996) cloned and characterized the human serotonin 5-HT-6 receptor gene, which encodes a 440-amino acid polypeptide. The amino acid sequence is 89% similar to a corrected rat sequence. By Northern blot analysis, they showed that the receptor is expressed in several human brain regions, most prominently in the caudate nucleus. Study of genomic clones revealed that the open reading frame is interrupted by 2 introns in positions corresponding to the third cytoplasmic loop and the third extracellular loop, respectively. The authors found an RsaI restriction fragment length polymorphism within the coding region.
Kohen et al. (1996) used Southern probing of a hybrid cell panel to map the HTR6 gene to chromosome 1p36-p35, not far from the location of the 5-HT-1D-alpha receptor (182133).
Kohen, R., Metcalf, M. A., Khan, N., Druck, T., Huebner, K., Lachowicz, J. E., Meltzer, H. Y., Sibley, D. R., Roth, B. L., Hamblin, M. W. Cloning, characterization, and chromosomal localization of a human 5-HT-6 serotonin receptor. J. Neurochem. 66: 47-56, 1996. [PubMed: 8522988] [Full Text: https://doi.org/10.1046/j.1471-4159.1996.66010047.x]
Monsma, F. J., Jr., McVittie, L. D., Gerfen, C. R., Mahan, L. C., Sibley, D. R. Multiple D(2) dopamine receptors produced by alternative RNA splicing. Nature 342: 926-929, 1989. [PubMed: 2480527] [Full Text: https://doi.org/10.1038/342926a0]
Ward, R. P., Hamblin, M. W., Lachowicz, J. E., Hoffman, B. J., Sibley, D. R., Dorsa, D. M. Localization of serotonin subtype 6 receptor messenger RNA in the rat brain by in situ hybridization histochemistry. Neuroscience 64: 1105-1111, 1995. [PubMed: 7753378] [Full Text: https://doi.org/10.1016/0306-4522(94)00439-c]