Alternative titles; symbols
HGNC Approved Gene Symbol: SOX15
Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,588,178-7,590,094 (from NCBI)
SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (602148).
By use of a SOX9 (608160) cDNA as a hybridization probe, Meyer et al. (1996) discovered a new member of the SOX gene family, which they called SOX20, but which was later designated SOX15 by the HUGO Nomenclature Committee. They found that SOX15 has a high similarity to the deduced amino acid sequence of human SOX12 (601947) and murine Sox16 HMG domains.
By PCR of human genomic DNA using highly degenerate oligonucleotides designed to amplify HMG box-related sequences, Cremazy et al. (1998) identified several novel SOX sequences, including SOX15, which they mistakenly reported as partial sequences of 2 separate genes designated SOX26 and SOX27.
By fluorescence in situ hybridization (FISH), Meyer et al. (1996) mapped the SOX15 gene to 17p13. Critcher et al. (1998) used FISH to refine the localization to 17p12.3. Vujic et al. (1998) assigned the SOX15 gene to 17p13.1 by the study of a radiation hybrid panel.
Lee et al. (2004) reported that Northern blot and RT-PCR analyses in mice showed that Sox15 is highly expressed in primary satellite cell-derived myoblasts but not in differentiated myogenic cells. Sox15-null mice were viable and fertile and showed normal skeletal muscle development. In particular, satellite cells were normal, excluding a role for Sox15 in the development of satellite cells; however, skeletal muscle regeneration was impaired in the Sox15-null mice after crush injury, and cultured Sox15-null myoblasts displayed a marked delay in differentiation potential compared to wildtype cells. Lee et al. (2004) concluded that SOX15 plays a role in the regulation of skeletal muscle myogenesis.
Cremazy, F., Soullier, S., Berta, P., Jay, P. Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR. FEBS Lett. 438: 311-314, 1998. [PubMed: 9827568] [Full Text: https://doi.org/10.1016/s0014-5793(98)01294-0]
Critcher, R., Stitson, R. N. M., Wade-Martins, R., Easty, D. J., Farr, C. J. Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3. Cytogenet. Cell Genet. 81: 294-295, 1998. [PubMed: 9730625] [Full Text: https://doi.org/10.1159/000015052]
Lee, H.-J., Goring, W., Ochs, M., Muhlfeld, C., Steding, G., Paprotta, I., Engel, W., Adham, I. M. Sox15 is required for skeletal muscle regeneration. Molec. Cell. Biol. 24: 8428-8436, 2004. [PubMed: 15367664] [Full Text: https://doi.org/10.1128/MCB.24.19.8428-8436.2004]
Meyer, J., Wirth, J., Held, M., Schempp, W., Scherer, G. SOX20, a new member of the SOX gene family, is located on chromosome 17p13. Cytogenet. Cell Genet. 72: 246-249, 1996. [PubMed: 8978787] [Full Text: https://doi.org/10.1159/000134200]
Vujic, M., Rajic, T., Goodfellow, P. N., Stevanovic, M. cDNA characterization and high resolution mapping of the human SOX20 gene. Mammalian Genome 9: 1059-1061, 1998. [PubMed: 9880678] [Full Text: https://doi.org/10.1007/s003359900925]