Entry - *601305 - 5-HYDROXYTRYPTAMINE RECEPTOR 5A; HTR5A - OMIM

 
 
* 601305

5-HYDROXYTRYPTAMINE RECEPTOR 5A; HTR5A


Alternative titles; symbols

SEROTONIN 5-HT-5A RECEPTOR


HGNC Approved Gene Symbol: HTR5A

Cytogenetic location: 7q36.2     Genomic coordinates (GRCh38): 7:155,070,324-155,087,392 (from NCBI)


TEXT

▼ Cloning and Expression

Rees et al. (1994) cloned the human serotonin receptor subtype HTR5A from genomic DNA. HTR5A encodes a deduced 357-amino acid protein with 7 transmembrane domains. RT-PCR analysis indicated that HTR5A is expressed exclusively in the brain, at higher levels in adult than in fetal tissues. No expression was seen in any peripheral tissue tested.


▼ Gene Structure

Rees et al. (1994) determined that the HTR5A gene contains 2 exons.


▼ Mapping

Schanen et al. (1996) used PCR analysis of somatic cell hybrid panels and a collection of chromosome 7-specific YAC clones to map HTR5A to 7q36.1.


▼ REFERENCES

  1. Rees, S., den Daas, I., Foord, S., Goodson, S., Bull, D., Kilpatrick, G., Lee, M. Cloning and characterisation of the human 5-HT5A serotonin receptor. FEBS Lett. 355: 242-246, 1994. [PubMed: 7988681, related citations] [Full Text]

  2. Schanen, N. C., Scherer, S. W., Tsui, L.-C., Francke, U. Assignment of the 5-hydroxytryptamine (serotonin) receptor 5A gene (HTR5A) to human chromosome band 7q36.1. Cytogenet. Cell Genet. 72: 187-188, 1996. [PubMed: 8978771, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 6/11/1996
Edit History:
carol : 04/11/2014
carol : 3/25/2014
mark : 6/10/1997
terry : 6/21/1996
mark : 6/11/1996

* 601305

5-HYDROXYTRYPTAMINE RECEPTOR 5A; HTR5A


Alternative titles; symbols

SEROTONIN 5-HT-5A RECEPTOR


HGNC Approved Gene Symbol: HTR5A

Cytogenetic location: 7q36.2     Genomic coordinates (GRCh38): 7:155,070,324-155,087,392 (from NCBI)


TEXT

Cloning and Expression

Rees et al. (1994) cloned the human serotonin receptor subtype HTR5A from genomic DNA. HTR5A encodes a deduced 357-amino acid protein with 7 transmembrane domains. RT-PCR analysis indicated that HTR5A is expressed exclusively in the brain, at higher levels in adult than in fetal tissues. No expression was seen in any peripheral tissue tested.


Gene Structure

Rees et al. (1994) determined that the HTR5A gene contains 2 exons.


Mapping

Schanen et al. (1996) used PCR analysis of somatic cell hybrid panels and a collection of chromosome 7-specific YAC clones to map HTR5A to 7q36.1.


REFERENCES

  1. Rees, S., den Daas, I., Foord, S., Goodson, S., Bull, D., Kilpatrick, G., Lee, M. Cloning and characterisation of the human 5-HT5A serotonin receptor. FEBS Lett. 355: 242-246, 1994. [PubMed: 7988681] [Full Text: https://doi.org/10.1016/0014-5793(94)01209-1]

  2. Schanen, N. C., Scherer, S. W., Tsui, L.-C., Francke, U. Assignment of the 5-hydroxytryptamine (serotonin) receptor 5A gene (HTR5A) to human chromosome band 7q36.1. Cytogenet. Cell Genet. 72: 187-188, 1996. [PubMed: 8978771] [Full Text: https://doi.org/10.1159/000134184]


Creation Date:
Victor A. McKusick : 6/11/1996

Edit History:
carol : 04/11/2014
carol : 3/25/2014
mark : 6/10/1997
terry : 6/21/1996
mark : 6/11/1996



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 20, 2024