Alternative titles; symbols
HGNC Approved Gene Symbol: UBE2G1
Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,269,259-4,366,675 (from NCBI)
Watanabe et al. (1996) isolated UBE2G1, which they designated UBE2G, from a human fetal brain cDNA library. The cDNA encodes a deduced 170-amino acid protein. The predicted peptide product shares 74% sequence identity with UBC7 of C. elegans, a high degree of homology with UBC7s of other species, and significant homologies with other subgroups of UBCs. Northern blot analysis revealed strong expression of transcripts of 3 sizes in skeletal muscle. Weak expression was observed in 15 other tissues examined.
Watanabe (2000) confirmed the mapping of a BAC (GenBank AC012479) containing most exons of the UBE2G gene to chromosome 17 by radiation hybrid mapping using 2 primer sets designed from the BAC sequence. By screening a human monochromosomal somatic cell hybrid panel with 3 distinct primers designed from UBE2G cDNA sequences, they further confirmed this localization. Watanabe (2000) stated that a previous mapping of the UBE2G gene to 1q42 was in error and may have represented the mapping of a pseudogene.
Watanabe, T. K., Kawai, A., Fujiwara, T., Maekawa, H., Hirai, Y., Nakamura, Y., Takahashi, E. Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans. Cytogenet. Cell Genet. 74: 146-148, 1996. [PubMed: 8893823] [Full Text: https://doi.org/10.1159/000134403]
Watanabe, T. K. Personal Communication. Tokushima, Japan 1/13/2000.