Alternative titles; symbols
HGNC Approved Gene Symbol: CORO2A
Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:98,120,975-98,192,637 (from NCBI)
By screening a human epidermal cDNA library with products identified through CpG island rescue PCR methodology, Zaphiropoulos and Toftgard (1996) isolated a CORO2A clone, which they called IR10. IR10 encodes a deduced 525-amino acid polypeptide with homology to several actin-binding proteins. The IR10 sequence contains 5 WD repeats. The IR10 gene is expressed as a 5-kb message in brain and several other human tissues, and as a 2-kb message in epidermis.
The IR10 gene contains of 2 putative exons (Zaphiropoulos and Toftgard, 1996).
Huang et al. (2011) provided evidence that CORO2A mediates Toll-like receptor (TLR; e.g., see 603029)-induced NCoR (600849) turnover by a mechanism involving interaction with oligomeric nuclear actin. SUMOylated liver X receptors (LXRs) block NCoR turnover by binding to a conserved SUMO2 (603042)/SUMO3 (602231)-interaction motif in CORO2A and preventing actin recruitment. Intriguingly, the LXR transrepression pathway can itself be inactivated by inflammatory signals that induce calcium/calmodulin-dependent protein kinase II-gamma (CAMK2G; 602123)-dependent phosphorylation of LXRs, leading to their deSUMOylation by the SUMO protease SENP3 (612844) and release from CORO2A. Huang et al. (2011) concluded that their findings uncovered a CORO2A-actin-dependent mechanism for the derepression of inflammatory response genes that can be differentially regulated by phosphorylation and by nuclear receptor signaling pathways that control immunity and homeostasis.
Zaphiropoulos and Toftgard (1996) identified the IR10 gene on chromosome 9q22.3.
Huang, W., Ghisletti, S., Saijo, K., Gandhi, M., Aouadi, M., Tesz, G. J., Zhang, D. X., Yao, J., Czech, M. P., Goode, B. L., Rosenfeld, M. G., Glass, C. K. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature 470: 414-418, 2011. [PubMed: 21331046] [Full Text: https://doi.org/10.1038/nature09703]
Zaphiropoulos, P. G., Toftgard, R. cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region. DNA Cell Biol. 15: 1049-1056, 1996. [PubMed: 8985118] [Full Text: https://doi.org/10.1089/dna.1996.15.1049]