Entry - *602939 - FORKHEAD BOX S1; FOXS1 - OMIM

 
 
* 602939

FORKHEAD BOX S1; FOXS1


Alternative titles; symbols

FORKHEAD, DROSOPHILA, HOMOLOG-LIKE 18; FKHL18
FORKHEAD-RELATED ACTIVATOR 10; FREAC10


HGNC Approved Gene Symbol: FOXS1

Cytogenetic location: 20q11.21     Genomic coordinates (GRCh38): 20:31,844,303-31,845,604 (from NCBI)


TEXT

▼ Cloning and Expression

The 'forkhead' family of transcription factors belongs to the winged helix class of DNA-binding proteins. By screening an adipose tissue library with a mixture of conserved forkhead domains from several gene family members, Cederberg et al. (1997) isolated cDNAs corresponding to a gene that they designated freac10, or FKHL18. Dot blot analysis of mRNA from 50 human tissues revealed that FKHL18 is expressed predominantly in the aorta and, to a lesser degree, in the kidney.


▼ Mapping

By analysis of a somatic cell hybrid panel and by fluorescence in situ hybridization, Cederberg et al. (1997) mapped the FKHL18 gene to 20q11.1-q11.2.


▼ REFERENCES

  1. Cederberg, A., Betz, R., Lagercrantz, S., Larsson, C., Hulander, M., Carlsson, P., Enerback, S. Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene. Genomics 44: 344-346, 1997. [PubMed: 9325056, related citations] [Full Text]


Creation Date:
Rebekah S. Rasooly : 8/5/1998
Edit History:
carol : 06/08/2012
carol : 6/8/2012
dkim : 12/8/1998
alopez : 8/5/1998

* 602939

FORKHEAD BOX S1; FOXS1


Alternative titles; symbols

FORKHEAD, DROSOPHILA, HOMOLOG-LIKE 18; FKHL18
FORKHEAD-RELATED ACTIVATOR 10; FREAC10


HGNC Approved Gene Symbol: FOXS1

Cytogenetic location: 20q11.21     Genomic coordinates (GRCh38): 20:31,844,303-31,845,604 (from NCBI)


TEXT

Cloning and Expression

The 'forkhead' family of transcription factors belongs to the winged helix class of DNA-binding proteins. By screening an adipose tissue library with a mixture of conserved forkhead domains from several gene family members, Cederberg et al. (1997) isolated cDNAs corresponding to a gene that they designated freac10, or FKHL18. Dot blot analysis of mRNA from 50 human tissues revealed that FKHL18 is expressed predominantly in the aorta and, to a lesser degree, in the kidney.


Mapping

By analysis of a somatic cell hybrid panel and by fluorescence in situ hybridization, Cederberg et al. (1997) mapped the FKHL18 gene to 20q11.1-q11.2.


REFERENCES

  1. Cederberg, A., Betz, R., Lagercrantz, S., Larsson, C., Hulander, M., Carlsson, P., Enerback, S. Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene. Genomics 44: 344-346, 1997. [PubMed: 9325056] [Full Text: https://doi.org/10.1006/geno.1997.4864]


Creation Date:
Rebekah S. Rasooly : 8/5/1998

Edit History:
carol : 06/08/2012
carol : 6/8/2012
dkim : 12/8/1998
alopez : 8/5/1998



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 18, 2024