Role of Apoptosis in Age-Related Pathologies

V. G. Zainullin* and A. A. Moskalev** * Institute of Biology, Komi Scientific Center of the Ural Branch, Russian Academy of Sciences, ul. Kommunisticheskaya 28, Syktyvkar, 167982 Russia ** Syktyvkar State University, Syktyvkar, 167982 Russia Abstract-A review of recent data concerning the apoptotic death of cells during senescence at the organismic level. The data analyzed suggest interrelations between apoptosis deregulation and some age-related pathologies and senescent phenotypes. Genetic aspects and possible mechanisms of age-related changes in the program of apoptosis are considered. It has been proposed that age-related deregulation of apoptosis is a mechanism of se- nescence.