Рис. SPTA seq.
Нуклеотидная и амнокислотная последовательности
гена альфа спектрина
tgtcgattg
tgtatggctgatgggattctaggaccaagcaagaggttttttttttttcccccacatac
ttaacgtttctatatttctatttgaattcgactggacagttccatttgaattatttctc
tctctctctctctctctctgacacattttatcttgccaggttctaaacctttaggaaaa
atg gag caa ttt cca aag gaa acc gtt gtg gag agc agt ggg cca
met glu gln phe pro lys glu thr val val glu ser ser gly pro 15
aag gtt ttg gaa aca gca gaa gag atc cag gag agg cgt cag gaa
lys val leu glu thr ala glu glu ile gln glu arg arg gln glu 30
gtg ttg act cgg tat caa agt ttc aag gag cgg gtt gct gag agg
val leu thr arg tyr gln ser phe lys gln arg val ala glu arg 45
ggt cag aag ctt gag gat tcc tat cac tta caa gtt ttc aag cga
gly gln lys leu glu asp ser tyr his leu gln val phe lys arg 60
gat gca gat gat ctg ggg aag tgg atc atg gag aaa gtc aat atc
asp ala asp asp leu gly lys trp ile met glu lys val asn ile 75
tta acc gat aag agc tat gaa gac cca act aat ata cag ggg aaa
leu the asp lys ser tyr glu asp pro thr asn ile gln gly lys 90
tat cag aag cat caa tcc ctt gaa gca gag gtg caa acg aaa tca
tyr gln lys his gln ser leu glu ala glu val gln thr lys ser 105
aga ctc atg tct gaa ctg gaa aaa aca agg gaa gaa cga ttt acc
arg leu met ser glu leu glu lys thr arg glu glu arg phe thr 120
atg ggt cat tct gcc cac gaa gaa acg aag gcc cat ata gag gag
met gly his ser ala his glu glu thr lys ala his ile glu glu 135
cta cgc cac ctg tgg gac ctg ctg tta gag ctg acc ctg gag aag
leu arg his leu trp asp leu leu leu glu leu thr leu glu lys 150
ggt gac cag ttg ctg cgg gcc ctg aag ttc cag cag tat gta cag
gly asp gln leu leu arg ala leu lys phe gln gln tyr val gln 165
gag tgt gct gac atc tta gag tgg att gga gac aag gag gct ata
glu cys ala asp ile leu glu trp ile gly asp lys glu ala ile 180
gcg aca tca gtg gag cta ggt gaa gac tgg gag cgc acc gaa gtt
ala thr ser val glu leu gly glu asp trp glu arg thr glu val 195
ctg cat aag aaa ttt gaa gac ttc caa gtg gag ctg gta gct aaa
leu his lys lys phe glu asp phe gln val glu leu val ala lys 210
gaa ggg aga gtt gtt gaa gtg aac caa tat gcc aat gag tgt gcc
glu gly arg val val glu val asn gln tyr ala asn glu cys ala 225
gag gaa aac cat cct gac cta ccc tta att cag tct aag caa aat
glu glu asn his pro asp leu pro leu ile gln ser lys gln asn 240
gag gtg aat gct gcc tgg gag cgc ctt cgt ggt ttg gct ctc cag
glu val asn ala ala trp glu arg leu arg glu leu ala leu gln 255
aga cag aaa gct ctg tcc aat gct gca aac tta caa cga ttc aaa
arg gln lys ala leu ser asn ala ala asn leu gln arg phe lys 270
agg gat gtg act gaa gcc atc cag tgg atc aag gag aag gaa cct
arg asp val thr glu ala ile gln trp ile lys glu lys glu pro 285
gta ctc acc tct gag gac tat ggc aaa gac ctt gtt gcc tct gaa
val leu thr ser glu asp tyr gly lys asp leu val ala ser glu 300
gga ctg ttt cac agc cac aag gga ctt gag aga aat ctt gca gtc
gly leu phe his ser his lys gly leu glua sp asn leu ala val 315
atg agt gac aag gtg aag gag tta tgt gct aaa gca gag aag ctg
met ser asp lys val lys glu leu cys ala lys ala glu lys leu 330
aca ctt tcc cat cct tca gat gca cct cag atc cag gag atg aaa
thr leu ser his pro ser asp ala pro gln ile gln glu met lys 345
gaa gat ctg gtc tcc agc tgg gag cat att cgt gcc ctg gcc acc
glu asp leu val ser ser trp glu his ile arg ala leu ala thr 360
agc aga tat gaa aaa ctg cag gct act tat tgg tac cat cga ttt
ser arg tyr glu lys leu gln ala thr tyr trp tyr his arg phe 375
tca tct gac ttt gat gaa ctc tca ggc tgg atg aac gag aag act
ser ser asp phe asp glu leu ser gly trp met asn glu lys thr 390
gct gcg atc aat gct gat gag ctg cca aca gat gtg gct ggt gga
ala ala ile asn ala asp glu leu pro thr asp val ala gly gly 405
gaa gtt ctg ctg gac agg cat cag cag cat aag cat gag att gac
glu val leu leu asp arg his gln gln his lys his glu ile asp 420
tct tac gat gac cga ttt caa tct gct gat gag act ggt caa gac
ser tyr asp asp arg phe gln ser ala asp glu thr gly gln asp 435
ctc gtg aat gcc aat cat gaa gcc tct gat gaa gtt cgg gaa aag
leu val asn ala asn his glu ala ser asp glu val arg glu lys 450
atg gaa ata ctt gac aac aac tgg act gcc ctg ctg gaa ctg tgg
met glu ile leu asp asn asn trp thr ala leu leu glu leu trp 465
gac gag cgt cat cgt cag tat gag cag tgc ttg gac ttt cat ctc
asp glu arg his arg gln tyr glu gln cys leu asp phe his leu 480
ttc tac aga gac agt gag caa gtg gac agt tgg atg agt aga caa
phe tyr arg asp ser glu gln val asp ser trp met ser arg gln 495
gag gcc ttc ctg gaa aac gag gat ctg gga aac tca ctg ggc agt
glu ala phe leu glu asn glu asp leu gly asn ser leu gly ser 510
gca gaa gcc ctt ctt cag aag cat gaa gac ttt gag gaa gcc ttt
ala glu ala leu leu gln lys his glu asp phe glu glu ala phe 525
act gcc cag gaa gag aag atc ata act gta gac aag act gca acc
thr ala gln glu glu lys ile ile thr val asp lys thr ala thr 540
aaa ttg att ggt gat gac cat tat gat tca gag aac atc aag gct
lys leu ile gly asp asp his tyr asp ser glu asn ile lys ala 555
atc cgt gac ggc ctg tta gcc cgg cgg gat gcc cta cgt gaa aag
ile arg asp gly leu leu ala arg arg asp ala leu arg glu lys 570
gct gcc act aga cgt aga ttg ctg aag gag tca ttg ctt ctg caa
ala ala thr arg arg arg leu leu lys glu ser leu leu leu gln 585
aaa ctg tat gag gac tca gat gac cta aag aac tgg atc aac aag
lys leu tyr glu asp ser asp asp leu lys asn trp ile asn lys 600
aag aaa aag ttg gca gat gat gaa gat tac aag gac ata cag aac
lys lys lys leu ala asp asp glu asp tyr lys asp ile gln asn 615
ttg aag agc agg gtt caa aag cag caa gtc ttt gaa aag gag ttg
leu lys ser arg val gln lys gln gln val phe glu lys glu leu 630
gca gtt aat aag acc cag ctg gaa aac ata cag aaa act ggc caa
ala val asn lys thr gln leu glu asn ile gln lys thr gly gln 645
gag atg att gag ggt ggt cac tat gcc tct gac aat gtg acc act
glu met ile glu gly gly his tyr ala ser asp asn val thr thr 660
cgt ctg agt gaa gtt gcc agc ctc tgg gag gag ttg ctg gag gct
arg leu ser glu val ala ser leu trp glu glu leu leu glu ala 675
aca aaa cag aaa ggg acc cag ttg cat gag gcc aac cag cag ctg
thr lys gln lys gly thr gln leu his glu ala asn gln gln leu 690
caa ttt gaa aat aat gca gaa gat ttg cag cgc tgg ctg gag gat
gln phe glu asn asn ala glu asp leu gln arg trp leu glu asp 705
gtt gag tgg caa gtc acc tct gag gat tat ggg aaa ggc ctg gcc
val glu trp gln val thr ser glu asp tyr gly lys gly leu ala 720
gag gta cag aat cga ctc agg aaa cac ggc ctc ctg gag tcg gct
glu val gln asn arg leu arg lys his gly leu leu glu ser ala 735
gtg gct gct cgt cag gat cag gtg gat atc ctt aca gac ctg gct
val ala ala arg gln asp gln val asp ile leu thr asp leu ala 750
gca tat ttt gaa gaa ata ggc cat cct gat tct aag gat ata agg
ala tyr phe glu glu ile gly his pro asp ser lys asp ile arg 765
gca agg caa gag tcc ttg gta tgc cga ttt gaa gct ctg aaa gag
ala arg gln glu ser leu val cys arg phe glu ala leu lys glu 780
cca ctg gcc acc cga aag aag aag ctc tta gac ctt ctc cat ctg
pro leu ala thr arg lys lys lys leu leu asp leu leu his leu 795
cag ctg att tgt aga gac aca gag gat gag gag gcc tgg atc caa
gln leu ile cys arg asp thr glu asp glu glu ala trp ile gln 810
gag act gaa ccc tca gct act tcc acc tac ctt gga aag gac ctg
glu thr glu pro ser ala thr ser thr tyr leu gly lys asp leu 825
att gct tcc aaa aag ctt ctg aat agg cat aga gtc atc ctg gag
ile ala ser lys lys leu leu asn arg his arg val ile leu glu 840
aac att gcc agc cat gaa cca cgc att caa gag ata aca gaa agg
asn ile ala ser his glu pro arg ile gln glu ile thr glu arg 855
gga aac aaa atg gta gag gaa gga cac ttt gct gca gaa gat gtg
gly asn lys met val glu glu gly his phe ala ala glu asp val 870
gcc tct agg gtc aag agt ttg aac cag aat atg gag tct ctc cgt
ala ser arg val lys ser leu asn gln asn met glu ser leu arg 885
gct cga gct gct agg cga caa aat gat ctt gaa gcc aat gtc cag
ala arg ala ala arg arg gln asn asp leu glu ala asn val gln 900
ttc cag cag tac ctg gct gac ctg cat gaa gca gaa aca tgg atc
phe gln gln tyr leu ala asp leu his glu ala glu thr trp ile 915
aga gag aag gaa cct att gta gat aat act aac tat ggt gct gat
arg glu lys glu pro ile val asp asn thr asn tyr gly ala asp 930
gaa gaa gca gct ggg gct ctt cta aag aag cat gag gcc ttt cta
glu glu ala ala gly ala leu leu lys lys his glu ala phe leu 945
tta gat ctc aat tca ttt gga gac agt atg aaa gct ctg cgg aat
leu asp leu asn ser phe gly asp ser met lys ala leu arg asn 960
cag gca aac gcc tgc cag caa caa cag gct gca cca gtg gag gga
gln ala asn ala cys gln gln gln gln ala ala pro val glu gly 975
gtt gct gga gaa caa agg gtc atg gct tta tat gac ttc cag gcc
val ala gly glu gln arg val met ala leu tyr asp phe gln ala 990
cgc agc ccc cga gaa gtc acc atg aag aaa ggt gat gtc tta acg
arg ser pro arg glu val thr met lys lys gly asp val leu thr 1005
ctg ctc agt tcc atc aat aag gac tgg tgg aag gtg gaa gct gct
leu leu set ser ile asn lys asp trp trp lys val glu ala ala 1020
gat cat cag ggc att gtc cca gct gtc tat gtc aga aga ctg gcc
asp lis gln gly ile val pro ala val tyr val arg arg leu ala 1035
cac gat gag ttc ccg atg ctc cca cag cgg cga cga gaa gag cca
his asp glu phe pro met leu pro gln arg arg arg glu glu pro 1050
gga aac atc acc cag cgc cag gag cag att gag aac caa tac cgc
gly asn ile thr gln arg gln glu gln ile glu asn gln tyr arg 1065
tcc ctc ttg gat cgg gca gaa gaa cgc aga cgt cgt cta ttg caa
ser leu leu asp arg ala glu glu arg arg arg arg leu leu gln 1080
cgt tat aat gaa ttt tta ttg gcc tat gag gca gga gac atg ctg
arg tyr asn glu phe leu leu ala tyr glu ala gly asp met leu 1095
gaa tgg att caa gag aaa aag gca gaa aac act gga gtg gaa cta
glu trp ile gln glu lys lys ala glu asn thr gly val glu leu 2010
gat gat gtt tgg gag ctg cag aaa aag ttt gat gag ttc caa aag
asp asp val trp glu leu gln lys lys phe asp glu phe gln lys 2025
gat ttg aat acc aat gag cct cgg cta agg gat atc aac aag gta
asp leu asn thr asn glu pro arg leu arg asp ile asn lys val 2040
gct gat gat cta cta ttt gaa gga ctt cta aca cca gaa gga gct
ala asp asp leu leu phe glu gly leu leu thr pro glu gly ala 2055
caa atc cgg cag gaa ttg aat gcc cgc tgg ggt tct ttg cag agg
gln ile arg gln glu leu asn ala arg trp gly ser leu gln arg 2070
ctt gca gat gaa cag cgg cag ctg ctg ggc agt gcc cat gct gtt
leu ala asp glu gln arg gln leu leu gly ser ala his ala val 2085
gaa gtg ttt cac aga gaa gca gat gac acg aag gag cag att gag
glu val phe his arg glu ala asp asp thr lys glu gln ile glu 2100
aag aaa tgc cag gcc ctc agt gct gca gac cct ggc tca gat ctg
lys lys cys gln ala leu ser ala ala asp pro gly ser asp leu 2115
ttc agt gtt cag gct ctt cag cga cgg cat gag ggc ttt gaa agg
phe ser val gln ala leu gln arg arg his glu gly phe glu arg 2130
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