Рис. F 8 seq
Нуклеотидная и аминокислотная
последовательности гена фактора коагуляции VIII (F 8)
-19
ATG CAA ATA GAG CTC TCC ACC TGC TTC TTT CTG TGC CTT TTG CGA
met gln ile glu leu ser thr cys phe phe leu cys leu leu arg 15
+1
TTC TGC TTT AGT GCC ACC AGA AGA TAC TAC CTG GGT GCA GTG GAA
phe cys phe ser ala thr arg arg tyr tyr leu gly ala val glu 30
CTG TCA TGG GAC TAT ATG CAA AGT GAT CTC GGT GAG CTG CCT GTG
leu ser trp asp tyr met gln ser asp leu gly glu leu pro val 45
GAC GCA AGA TTT CCT CCT AGA GTG CCA AAA TCT TTT CCA TTC AAC
asp ala arg phe pro pro arg val pro lys ser phe pro phe asn 60
ACC TCA GTG GTG TAC AAA AAG ACT CTG TTT GTA GAA TTC ACG GAT
thr ser val val tyr lys lys thr leu phe val glu phe thr asp 75
CAC CTT TTC AAC ATC GCT AAG CCA AGG CCA CCC TGG ATG GGT CTG
his leu phe asn ile ala lys pro arg pro pro trp met gly leu 90
CTA GGT CTT ACC ATC CAG GCT GAG GTT TAT GAT ACA GTG GTC ATT
leu gly pro thr ile gln ala glu val tyr asp thr val val ile 105
ACA CTT AAG AAC ATG GCT TCC CAT CCT GTC AGT CTT CAT GCT GTT
thr leu lys asn met ala ser his pro val ser leu his ala val 120
GGT GTA TCC TAC TGG AAA GCT TCT GAG GGA GCT GAA TAT GAT GAT
gly val ser tyr trp lys ala ser glu gly ala glu tyr asp asp 135
CAG ACC AGT CAA AGG GAG AAA GAA GAT GAT AAA GTC TTC CCT GGT
gln thr ser gln arg glu lys glu asp asp lys val phe pro gly 150
GGA AGC CAT ACA TAT GTC TGG CAG GTC CTG AAA GAG AAT GGT CCA
gly ser his thr tyr val trp gln val leu lys glu asp gly pro 165
ATG GCC TCT GAC CCA CTG TGC CTT ACC TAC TCA TAT CTT TCT CAT
met ala ser asp pro leu cys leu thr tyr ser tyr leu ser his 180
GTG GAC CTG GTA AAA GAC TTG AAT TCA GGC CTC ATT GGA GCC CTA
val asp leu val lys asp leu asn ser gly leu ile gly ala leu 195
CTA GTA TGT AGA GAA GGG AGT CTG GCC AAG GAA AAG ACA CAG ACC
leu val cys arg glu gly ser leu ala lys glu lys thr gln thr 210
TTG CAC AAA TTT ATA CTA CTT TTT GCT GTA TTT GAT GAA GGG AAA
leu his lys phe ile leu leu phe ala val phe asp glu gly lys 225
AGT TGG CAC TCA GAA ACA AAG AAC TCC TTG ATG CAG GAT AGG GAT
ser trp his ser glu thr lys asn ser leu met gln asp arg asp 240
GCT GCA TCT GCT CGG GCC TGG CCT AAA ATG CAC ACA GTC AAT GGT
ala ala ser ala arg ala trp pro lys met his thr val asn gly 255
TAT GTA AAC AGG TCC CTG CCA GGT CTG ATT GGA TGC CAC AGG AAA
tyr val asn arg ser leu pro gly leu ile gly cys his arg lys 270
TCA GTC TAT TGG CAT GTG ATT GGA ATG GGC ACC ACT CCT GAA GTG
ser val tyr trp his val ile gly met gly thr thr pro glu val 285
CAC TCA ATA TTC CTC GAA GGT CAC ACA TTT CTT GTG AGG AAC CAT
his ser ile phe leu glu gly his thr phe leu val arg asn his 300
CGC CAG GCG TCC TTG GAA ATC TCG CCA ATA ACT TTC CTT ACT GCT
arg gln ala ser leu glu ile ser pro ile thr phe leu thr ala 315
CAA ACA CTC TTG ATG GAC CTT GGA CAG TTT CTA CTG TTT TGT CAT
gln thr leu leu met asp leu gly gln phe leu leu phe cys his 330
ATC TCT TCC CAC CAA CAT GAT GGC ATG GAA GCT TAT GTC AAA GTA
ile ser ser his gln his asp gly met glu ala tyr val lys val 345
GAC AGC TGT CCA GAG GAA CCC CAA CTA CGA ATG AAA AAT AAT GAA
asp ser cys pro glu glu pro gln leu arg met lys asn asn glu 360
GAA GCG GAA GAC TAT GAT GAT GAT CTT ACT GAT TCT GAA ATG GAT
glu ala glu asp tyr asp asp asp leu thr asp ser glu met asp 375
GTG GTC AGG TTT GAT GAT GAC AAC TCT CCT TCC TTT ATC CAA ATT
val val arg phe asp asp asp asn ser pro ser phe ile gln ile 390
CGC TCA GTT GCC AAG AAG CAT CCT AAA ACT TGG GTA CAT TAC ATT
arg ser val ala lys lys his pro lys thr trp val his tyr ile 405
GCT GCT GAA GAG GAG GAC TGG GAC TAT GCT CCC TTA GTC CTC GCC
ala ala glu glu glu asp trp asp tyr ala pro leu val leu ala 420
CCC GAT GAC AGA AGT TAT AAA AGT CAA TAT TTG AAC AAT GGC CCT
pro asp asp arg ser tyr lys ser gln tyr leu asn asn gly pro 435
CAG CGG ATT GGT AGG AAG TAC AAA AAA GTC CGA TTT ATG GCA TAC
gln arg ile gly arg lys tyr lys lys val arg phe met ala tyr 450
ACA GAT GAA ACC TTT AAG ACT CGT GAA GCT ATT CAG CAT GAA TCA
thr asp glu thr phe lys thr arg glu ala ile gln his glu ser 465
GGA ATC TTG GGA CCT TTA CTT TAT GGG GAA GTT GGA GAC ACA CTG
gly ile leu gly pro leu leu tyr gly glu val gly asp thr leu 480
TTG ATT ATA TTT AAG AAT CAA GCA AGC AGA CCA TAT AAC ATC TAC
leu ile ile phe lys asn gln ala aer arg pro tyr asn ile tyr 495
CCT CAC GGA ATC ACT GAT GTC CGT CCT TTG TAT TCA AGG AGA TTA
pro his gly ile thr asp val arg pro leu tyr ser arg arg leu 510
CCA AAA GGT GTA AAA CAT TTG AAG GAT TTT CCA ATT CTG CCA GGA
pro lys gly val lys his leu lys asp phe pro ile leu pro gly 525
GAA ATA TTC AAA TAT AAA TGG ACA GTG ACT GTA GAA GAT GGG CCA
glu ile phe lys tyr lys trp thr val thr val glu asp gly pro 540
ACT AAA TCA GAT CCT CGG TGC CTG ACC CGC TAT TAC TCT AGT TTC
thr lys ser asp pro arg cys leu thr arg tyr tyr ser ser phe 555
GTT AAT ATG GAG AGA GAT CTA GCT TCA GGA CTC ATT GGC CCT CTC
val asn met glu arg asp leu ala ser gly leu ile gly pro leu 570
CTC ATC TGC TAC AAA GAA TCT GTA GAT CAA AGA GGA AAC CAG ATA
leu ile cys tyr lys glu ser val asp gln arg gly asn gln ile 585
ATG TCA GAC AAG AGG AAT GTC ATC CTG TTT TCT GTA TTT GAT GAG
met ser asp lys arg asn val ile leu phe ser val phe asp glu 600
AAC CGA AGC TGG TAC CTC ACA GAG AAT ATA CAA CGC TTT CTC CCC
asn arg ser trp tyr leu thr glu asp ile gln arg phe leu pro 615
AAT CCA GCT GGA GTG CAG CTT GAG GAT CCA GAG TTC CAA GCC TCC
asn pro ala gly val gln leu glu asp pro glu phe gln ala ser 630
AAC ATC ATG CAC AGC ATC AAT GGG TAT GTT TTT GAT AGT TTG CAG
asn ile met his ser ile asn gly tyr val phe asp ser leu gln 645
TTG TCA GTT TGT TTG CAT GAG GTG GCA TAC TGG TAC ATT CTA AGC
leu ser val cys leu his glu val ala tyr trp tyr ile leu ser 660
ATT GGA GCA CAG ACT GAC TTC CTT TCT GTC TTC TTC TCT GGA TAT
ile gly ala gln thr asp phe leu ser val phe phe ser gly tyr 675
ACC TTC AAA CAC AAA ATG GTC TAT GAA GAC ACA CTC ACC CTA TTC
thr phe lys his lys met val tyr glu asp thr leu thr leu phe 690
CCA TTC TCA GGA GAA ACT GTC TTC ATG TCG ATG GAA AAC CCA GGT
pro phe ser gly glu thr val phe met ser met glu asn pro gly 705
CTA TGG ATT CTG GGG TGC CAC AAC TCA GAC TTT CGG AAC AGA GGC
leu trp ile leu gly cys his asn ser asp phe arg asn arg gly 720
ATG ACC GCC TTA CTG AAG GTT TCT AGT TGT GAC AAG AAC ACT GGT
met thr ala leu leu lys val ser ser cys asp lys asn thr gly 735
GAT TAT TAC GAG GAC AGT TAT GAA GAT ATT TCA GCA TAC TTG CTG
asp tyr tyr glu asp ser tyr glu asp ile ser ala tyr leu leu 750
AGT AAA AAC AAT GCC ATT GAA CCA AGA AGC TTC TCC CAG AAT TCA
ser lys asn asn ala ile glu pro arg ser phe ser gln asn ser 765
AGA CAC CCT AGC ACT AGG CAA AAG CAA TTT AAT GCC ACC ACA ATT
arg his pro ser thr arg gln lys gln phe asn ala thr thr ile 780
CCA GAA AAT GAC ATA GAG AAG ACT GAC CCT TGG TTT GCA CAC AGA
pro glu asn asp ile glu lys thr asp pro trp phe ala his arg 795
ACA CCT ATG CCT AAA ATA CAA AAT GTC TCC TCT AGT GAT TTG TTG
thr pro met pro lys ile gln asn val ser ser ser asp leu leu 810
ATG CTC TTG CGA CAG AGT CCT ACT CCA CAT GGG CTA TCC TTA TCT
met leu leu arg gln ser pro thr pro his gly leu ser leu ser 825
GAT CTC CAA GAA GCC AAA TAT GAG ACT TTT TCT GAT GAT CCA TCA
asp leu gln glu ala lys tyr glu thr phe ser asp asp pro ser 840
CCT GGA GCA ATA GAC AGT AAT AAC AGC CTG TCT GAA ATG ACA CAC
pro gly ala ile asp ser asn asn ser leu ser glu met thr his 855
TTC AGG CCA CAG CTC CAT CAC AGT GGG GAC ATG GTA TTT ACC CCT
phe arg pro gln leu his his ser gly asp met val phe thr pro 870
CAG TCA GGC CTC CAA TTA AGA TTA AAT GAG AAA CTG GGG ACA ACT
glu ser gly leu gln leu arg leu asn glu lys leu gly thr thr 885
GCA GCA ACA GAG TTG AAG AAA CTT GAT TTC AAA GTT TCT AGT ACA
ala ala thr glu leu lys lys leu asp phe lys val ser ser thr 900
TCA AAT AAT CTG ATT TCA ACA ATT CCA TCA GAC AAT TTG GCA GCA
ser asn asn leu ile ser thr ile pro ser asp asn leu ala ala 915
GGT ACT GAT AAT ACA AGT TCC TTA GGA CCC CCA AGT ATG CCA GTT
gly thr asp asn thr ser ser leu gly pro pro ser met pro val 930
CAT TAT GAT AGT CAA TTA GAT ACC ACT CTA TTT GGC AAA AAG TCA
his tyr asp ser gln leu asp thr thr leu phe gly lys lys ser 945
TCT CCC CTT ACT GAG TCT GGT GGA CCT CTG AGC TTG AGT GAA GAA
ser pro leu thr glu ser gly gly pro leu ser leu ser glu glu 960
AAT AAT GAT TCA AAG TTG TTA GAA TCA GGT TTA ATG AAT AGC CAA
asn asn asp ser lys leu leu glu ser gly leu met asn ser gln 975
GAA AGT TCA TGG GGA AAA AAT GTA TCG TCA ACA GAG AGT GGT AGG
glu ser ser trp gly lys asn val ser ser thr glu ser gly arg 990
TTA TTT AAA GGG AAA AGA GCT CAT GGA CCT GCT TTG TTG ACT AAA
leu phe lys gly lys arg ala his gly pro ala leu leu thr lys 1005
GAT AAT GCC TTA TTC AAA GTT AGC ATC TCT TTG TTA AAG ACA AAC
asp asn ala leu phe lys val ser ile ser leu leu lys thr asn 1020
AAA ACT TCC AAT AAT TCA GCA ACT AAT AGA AAG ACT CAC ATT GAT
lys thr ser asn asn ser ala thr asn arg lys thr his ile asp 1035
GGC CCA TCA TTA TTA ATT GAG AAT AGT CCA TCA GTC TGG CAA AAT
gly pro ser leu leu ile glu asn ser pro ser val trp gln asn 1050
ATA TTA GAA AGT GAC ACT GAG TTT AAA AAA GTG ACA CCT TTG ATT
ile leu glu ser asp thr glu phe lys lys val thr pro leu ile 1065
CAT GAC AGA ATG CTT ATG GAC AAA AAT GCT ACA GCT TTG AGG CTA
his asp arg met leu met asp lys asn ala thr ala leu arg leu 1080
AAT CAT ATG TCA AAT AAA ACT ACT TCA TCA AAA AAC ATG GAA ATG
asn his met ser asn lys thr thr ser ser lys asn met glu met 1095
GTC CAA CAG AAA AAA GAG GGC CCC ATT CCA CCA GAT GCA CAA AAT
val gln gln lys lys glu gly pro ile pro pro asp ala gln asn 1110
CCA GAT ATG TCG TTC TTT AAG ATG CTA TTC TTG CCA GAA TCA GCA
pro asp met ser phe phe lys met leu phe leu pro glu ser ala 1125
AGG TGG ATA CAA AGG ACT CAT GGA AAG AAC TCT CTG AAC TCT GGG
arg trp ile gln arg thr his gly lys asn ser leu asn ser gly 1140
CAA GGC CCC AGT CCA AAG CAA TTA GTA TCC TTA GGA CCA GAA AAA
gln gly pro ser pro lys gln leu val ser leu gly pro glu lys 1155
TCT GTG GAA GGT CAG AAT TTC TTG TCT GAG AAA AAC AAA GTG GTA
ser val glu gly gln asn phe leu ser glu lys asn lys val val 1170
GTA GGA AAG GGT GAA TTT ACA AAG GAC GTA GGA CTC AAA GAG ATG
val gly lys gly glu phe thr lys asp val gly leu lys glu met 1185
GTT TTT CCA AGC AGC AGA AAC CTA TTT CTT ACT AAC TTG GAT AAT
val phe pro ser ser arg asn leu phe leu thr asn leu asp asn 1200
TTA CAT GAA AAT AAT ACA CAC AAT CAA GAA AAA AAA ATT CAG GAA
leu his glu asn asn thr his asn gln glu lys lys ile gln glu 1215
GAA ATA GAA AAG AAG GAA ACA TTA ATC CAA GAG AAT GTA GTT TTG
glu ile glu lys lys glu thr leu ile gln glu asn val val leu 1230
CCT CAG ATA CAT ACA GTG ACT GGC ACT AAG AAT TTC ATG AAG AAC
pro gln ile his thr val thr gly thr lys asn phe met lys asn 1245
CTT TTC TTA CTG AGC ACT AGG CAA AAT GTA GAA GGT TCA TAT GAC
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