Рис. F 13a seq
Нуклеотидная и аминокислотная последовательности
гена фактора XIIIA человека.
-1 +1
ATG TCA GAA ACT TCC AGG ACC GCC TTT GGA GGC AGA AGA GCA GTT
met ser glu thr ser arg thr ala phe gly gly arg arg ala val 15
CCA CCC AAT AAC TCT AAT GCA GCG GAA GAT GAC CTG CCC ACA GTG
pro pro asn asn ser asn ala ala gln asp asp leu pro thr val 30
GAG CTT CAG GGC GTG GTG CCC CGG GGC GTC AAC CTG CAA GAG TTT
glu leu gln gly val val pro arg gly val asn leu gln glu phe 45
CTT AAT GTC ACG AGC GTT CAC CTG TTC AAG GAG AGA TGG GAC ACT
leu asn val thr ser val his leu phe lys glu arg trp asp thr 60
AAC AAG GTG GAC CAC CAC ACT GAC AAG TAT GAA AAC AAC AAG CTG
asn lys val asp his his thr asp lys tyr glu asn asn lys leu 75
ATT GTC CGC AGA GGG CAG TCT TTC TAT GTG CAG ATT GAC CTC AGT
ile val arg arg gly gln ser phe tyr val gln ile asp leu ser 90
CGT CCA TAT GAC CCC AGA AGG GAT CTC TTC AGG GTG GAA TAC GTC
arg pro tyr asp pro arg arg asp leu phe arg val glu tyr val 105
ATT GGT CGC TAC CCA CAG GAG AAC AAG GGA ACC TAC ATC CCA GTG
ile gly arg tyr pro gln glu asn lys gly thr tyr ile pro val 120
CCT ATA GTC TCA GAG TTA CAA AGT GGA AAG TGG GGG GCC AAG ATT
pro ile val ser glu leu gln ser gly lys trp gly ala lys ile 135
GTC ATG AGA GAG GAC AGG TCT GTG CGG CTG TCC ATC CAG TCT TCC
val met arg glu asp arg ser val arg leu ser ile gln ser ser 150
CCC AAA TGT ATT GTG GGG AAA TTC CGC ATG TAT GTT GCT GTC TGG
pro lys cys ile val gly lys phe arg met tyr val ala val trp 165
ACT CCC TAT GGC GTA CTT CGA ACC AGT CGA AAC CCA GAA ACA GAC
thr pro tyr gly val leu arg thr ser arg asn pro glu thr asp 180
ACG TAC ATT CTC TTC AAT CCT TGG TGT GAA GAT GAT GCT GTG TAT
thr tyr ile leu phe asn pro trp cys glu asp asp ala val tyr 195
CTG GAC AAT GAG AAA GAA AGA GAA GAG TAT GTC CTG AAT GAC ATC
leu asp asn glu lys glu arg glu glu tyr val leu asn asp ile 210
GGG GTA ATT TTT TAT GGA GAG GTC AAT GAC ATC AAG ACC AGA AGC
gly val ile phe tyr gly glu val asn asp ile lys thr arg ser 225
TGG AGC TAT GGT CAG TTT GAA GAT GGC ATC CTG GAC ACT TGC CTG
trp ser tyr gly gln phe glu asp gly ile leu asp thr cys leu 240
TAT GTG ATG GAC AGA GCA CAA ATG GAC CTC TCT GGA AGA GGG AAT
tyr val met asp arg ala gln met asp leu ser gly arg gly asn 255
CCC ATC AAA GTC AGC CGT GTG GGG TCT GCA ATG GTG AAT GCC AAA
pro ile lys val ser arg val gly ser ala met val asn ala lys 270
GAT GAC GAA GGT GTC CTC GTT GGA TCC TGG GAC AAT ATC TAT GCC
asp asp glu gly val leu val gly ser trp asp asn ile tyr ala 285
TAT GGC GTC CCC CCA TCG GCC TGG ACT GGA AGC GTT GAC ATT CTA
tyr gly val pro pro ser ala trp thr gly ser val asp ile leu 300
TTG GAA TAC CGG AGC TCT GAG AAT CCA GTC CGG TAT GGC CAA TGC
leu glu tyr arg ser ser glu asn pro val arg tyr gly gln cys 315
TGG GTT TTT GCT GGT GTC TTT AAC ACA TTT TTA CGA TGC CTT GGA
trp val phe ala gly val phe asn thr phe leu arg cys leu gly 330
ATA CCA GCA AGA ATT GTT ACC AAT TAT TTC TCT GCC CAT GAT AAT
ile pro ala arg ile val thr asn tyr phe ser ala his asp asn 345
GAT GCC AAT TTG CAA ATG GAC ATC TTC CTG GAA GAA GAT GGG AAC
asp ala asn leu gln met asp ile phe leu glu glu asp gly asn 360
GTG AAT TCC AAA CTC ACC AAG GAT TCA GTG TGG AAC TAC CAC TGC
val asn ser lys leu thr lys asp ser val trp asn tyr his cys 375
TGG AAT GAA GCA TGG ATG ACA AGG CCT GAC CTT CCT GTT GGA TTT
trp asn glu ala trp met thr arg pro asp leu pro val gly phe 390
GGA GGC TGG CAA GCT GTG GAC AGC ACC CCC CAG GAA AAT AGC GAT
gly gly trp gln ala val asp ser thr pro gln glu asn ser asp 405
GGC ATG TAT CGG TGT GGC CCC GCC TCG GTT CAA GCC ATC AAG CAC
gly met tyr arg cys gly pro ala ser val gln ala ile lys his 420
GGC CAT GTC TGC TTC CAA TTT GAT GCA CCT TTT GTT TTT GCA GAG
gly his val cys phe gln phe asp ala pro phe val phe ala glu 435
GTC AAC AGC GAC CTC ATT TAC ATT ACA GCT AAG AAA GAT GGC ACT
val asn ser asp leu ile tyr ile thr ala lys lys asp gly thr 450
CAT GTG GTG GAA AAT GTG GAT GCC ACC CAC ATT GGG AAA TTA ATT
his val val glu asn val asp ala thr his ile gly lys leu ile 465
GTG ACC AAA CAA ATT GGA GGA GAT GGC ATG ATG GAT ATT ACT GAT
val thr lys gln ile gly gly asp gly met met asp ile thr asp 480
ACT TAC AAA TTC CAA GAA GGT CAA GAA GAA GAG AGA TTG GCC CTA
thr tyr lys phe gln glu gly gln glu glu glu arg leu ala leu 495
GAA ACT GCC CTG ATG TAC GGA GCT AAA AAG CCC CTC AAC ACA GAA
glu thr ala leu met tyr gly ala lys lys pro leu asn thr glu 510
GGT GTC ATG AAA TCA AGG TCC AAC GTT GAC ATG GAC TTT GAA GTG
gly val met lys ser arg ser asn val asp met asp phe glu val 525
GAA AAT GCT GTG CTG GGA AAA GAC TTC AAG CTC TCC ATC ACC TTC
glu asn ala val leu gly lys asp phe lys leu ser ile thr phe 540
CGG AAC AAC AGC CAC AAC CGT TAC ACC ATC ACA GCT TAT CTC TCA
arg asn asn ser his asn arg tyr thr ile thr ala tyr leu ser 555
GCC AAC ATC ACC TTC TAC ACC GGG GTC CCG AAG GCA GAG TTC AAG
ala asn ile thr phe tyr thr gly val pro lys ala glu phe lys 570
AAG GAG ACG TTC GAC GTG ACG CTG GAG CCC TTG TCC TTC AAG AAA
lys glu thr phe asp val thr leu glu pro leu ser phe lys lys 585
GAG GCG GTG CTG ATC CAA GCC GGC GAG TAC ATG GGT CAG CTG CTG
glu ala val leu ile gln ala gly glu tyr met gly gln leu leu 600
GAA CAA GCG TCC CTG CAC TTC TTT GTC ACA GCT CGC ATC AAT GAG
glu gln ala ser leu his phe phe val thr ala arg ile asn glu 615
ACC AGG GAT GTT CTG GCC AAG CAA AAG TCC ACC GTG CTA ACC ATC
thr arg asp val leu ala lys gln lys ser thr val leu thr ile 630
CCT GAG ATC ATC ATC AAG GTC CGT GGC ACT CAG GTA GTT GGT TCT
pro glu ile ile ile lys val arg gly thr gln val val gly ser 645
GAC ATG ACT GTG ACA GTT CAG TTT ACC AAT CCT TTA AAA GAA ACC
asp met thr val thr val gln phe thr asn pro leu lys glu thr 660
CTG CGA AAT GTC TGG GTA CAC CTG GAT GGT CCT GGA GTA ACA AGA
leu arg asn val trp val his leu asp gly pro gly val thr arg 675
CCA ATG AAG AAG ATG TTC CGT GAA ATC CGG CCC AAC TCC ACC GTG
pro met lys lys met phe arg glu ile arg pro asn ser thr val 690
CAG TGG GAA GAA GTG TGC CGG CCC TGG GTC TCT GGG CAT CGG AAG
gln trp glu glu val cys arg pro trp val ser gly his arg lys 705
CTG ATA GCC AGC ATG AGC AGT GAC TCC CTG AGA CAT GTG TAT GGC
leu ile ala ser met ser ser asp ser leu arg his val tyr gly 720
GAG CTG GAC GTG CAG ATT CAA AGA CGA CCT TCC ATG TGA
glu leu asp val gln ile gln arg arg pro ser met ter
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