Рис. F 13b seq
Нуклеотидная и аминокислотная последовательности
гена фактора XIIIb человека.
-20
ATG AGG TTG AAA AAC CTG ACT TTT ATC ATC ATA TTG ATA ATC TCA
met arg leu lys asn leu thr phe ile ile ile leu ile ile ser 15
+1
GGA GAA CTC TAT GCA GAA GAG AAA CCC TGT GGT TTT CCT CAT GTG
gly glu leu tyr ala glu glu lys pro cys gly phe pro his val 30
GAA AAT GGA AGA ATT GCC CAA TAT TAC TAT ACT TTT AAA AGC TTT
glu asn gly arg ile ala gln tyr tyr tyr thr phe lys ser phe 45
TAC TTT CCA ATG AGC ATA GAC AAA AAA TTG TCA TTT TTC TGC TTG
tyr phe pro met ser ile asp lys lys leu ser phe phe cys leu 60
GCT GGT TAT ACC ACT GAA AGT GGA AGA CAA GAA GAG CAA ACC ACG
ala gly tyr thr thr glu ser gly arg gln glu glu gln thr thr 75
TGT ACA ACA GAA GGC TGG TCT CCA GAG CCA AGG TGC TTC AAA AAA
cys thr thr glu gly trp ser pro glu pro arg cys phe lys lys 90
TGC ACT AAG CCT GAC CTG AGT AAT GGT TAC ATC TCT GAT GTA AAG
cys thr lys pro asp leu ser asn gly tyr ile ser asp val lys 105
TTA TTG TAT AAA ATT CAA GAG AAC ATG CAT TAT GGT TGC GCT TCA
leu leu tyr lys ile gln glu asn met his tyr gly cys ala ser 120
GGG TAC AAA ACC ACT GGA GGG AAG GAT GAA GAA GTG GTT CAA TGT
gly tyr lys thr thr gly gly lys asp glu glu val val gln cys 135
CTC TCT GAT GGA TGG TCT TCT CAA CCA ACC TGT AGG AAA GAA CAT
leu ser asp gly trp ser ser gln pro thr cys arg lys glu his 150
GAA ACG TGT TTG GCT CCT GAA TTA TAT AAT GGA AAT TAT TCC ACA
glu thr cys leu ala pro glu leu tyr asn gly asn tyr ser thr 165
ACA CAG AAA ACA TTC AAA GTG AAG GAC AAA GTA CAA TAC GAA TGT
thr gln lys thr phe lys val lys asp lys val gln tyr glu cys 180
GCT ACT GGC TAC TAC ACA GCT GGA GGA AAG AAG ACA GAG GAG GTA
ala thr gly tyr tyr thr ala gly gly lys lys thr glu glu val 195
GAA TGT CTC ACA TAC GGA TGG TCT CTC ACA CCA AAA TGT ACC AAA
glu cys leu thr tyr gly trp ser leu thr pro lys cys thr lys 210
TTA AAG TGC TCT TCT TTA AGA TTA ATT GAA AAT GGT TAT TTT CAT
leu lys cys ser ser leu arg leu ile glu asn gly tyr phe his 225
CCT GTA AAG CAA ACC TAT GAA GAA GGA GAT GTC GTT CAG TTT TTC
pro val lys gln thr tyr glu glu gly asp val val gln phe phe 240
TGT CAT GAA AAT TAT TAT CTA AGT GGA TCT GAT TTA ATT CAA TGC
cys his glu asn tyr tyr leu ser gly ser asp leu ile gln cys 255
TAT AAC TTT GGT TGG TAC CCA GAA TCT CCT GTA TGC GAA GGA AGA
tyr asn phe gly trp tyr pro glu ser pro val cys glu gly arg 270
AGA AAC AGA TGT CCT CCT CCA CCT CTG CCC ATA AAC TCC AAA ATT
arg asn arg cys pro pro pro pro leu pro ile asn ser lys ile 285
CAA ACA CAT TCA ACA ACT TAT CGT CAT GGA GAA ATA GTT CAT ATA
gln thr his ser thr thr tyr arg his gly glu ile val his ile 300
GAA TGT GAA CTT AAT TTT GAG ATC CAT GGG TCA GCA GAA ATA CGT
glu cys glu leu asn phe glu ile his gly ser ala glu ile arg 315
TGT GAA GAT GGA AAA TCG ACA GAA CCT CCA AAA TGC ATT GAA GGA
cys glu asp gly lys ser thr glu pro pro lys cys ile glu gly 330
CAG GAG AAG GTA GCC TGT GAG GAA CCA CCC TTC ATT GAA AAT GGT
gln glu lys val ala cys glu glu pro pro phe ile glu asn gly 345
GCA GCA AAT TTA CAC TCT AAG ATT TAT TAC AAT GGG GAT AAA GTG
ala ala asn leu his ser lys ile tyr tyr asn gly asp lys val 360
ACA TAT GCA TGT AAA AGC GGC TAC CTT CTC CAT GGA TCG AAT GAG
thr tyr ala cys lys ser gly tyr leu leu his gly ser asn glu 375
ATA ACT TGT AAT CGT GGA AAA TGG ACA CTT CCT CCT GAG TGT GTT
ile thr cys asn arg gly lys trp thr leu pro pro glu cys val 390
GAA AAT AAT GAG AAT TGT AAG CAT CCT CCT GTT GTA ATG AAT GGG
glu asn asn glu asn cys lys his pro pro val val met asn gly 405
GCT GTT GCA GAC GGG ATA TTG GCA AGC TAT GCA ACA GGA TCC TCA
ala val ala asp gly ile leu ala ser tyr ala thr gly ser ser 420
GTG GAA TAT AGA TGC AAT GAA TAT TAC TTA CTG AGG GGA TCA AAA
val glu tyr arg cys asn glu tyr tyr leu leu arg gly ser lys 435
ATA TCT CGT TGC GAA CAA GGA AAA TGG TCA TCC CCA CCT GTT TGC
ile ser arg cys glu gln gly lys trp ser ser pro pro val cys 450
TTG GAA CCA TGT ACT GTT AAT GTG GAT TAC ATG AAC AGA AAT AAC
leu glu pro cys thr val asn val asp tyr met asn arg asn asn 465
ATA GAA ATG AAG TGG AAA TAT GAA GGG AAA GTC TTA CAT GGA GAT
ile glu met lys trp lys tyr glu gly lys val leu his gly asp 480
TTA ATA GAT TTT GTA TGT AAA CAG GGA TAT GAC TTA TCT CCA TTA
leu ile asp phe val cys lys gln gly tyr asp leu ser pro leu 495
ACC CCA TTG TCT GAA TTA TCT GTG CAG TGC AAC AGA GGA GAA GTG
thr pro leu ser glu leu ser val gln cys asn arg gly glu val 510
AAA TAT CCT TTA TGT ACT AGA AAA GAA TCT AAA GGA ATG TGC ACA
lys tyr pro leu cys thr arg lys glu ser lys gly met cys thr 525
TCT CCT CCT CTT ATT AAA CAT GGA GTC ATT ATT AGT TCA ACA GTA
ser pro pro leu ile lys his gly val ile ile ser ser thr val 540
GAC ACC TAT GAA AAT GGC TCT TCA GTA GAA TAC AGA TGT TTT GAT
asp thr tyr glu asn gly ser ser val glu tyr arg cys phe asp 555
CAC CAT TTC CTA GAA GGA TCT AGG GAG GCC TAT TGT TTA GAT GGA
his his phe leu glu gly ser arg glu ala tyr cys leu asp gly 570
ATG TGG ACT ACA CCA CCA TTG TGT TTA GAG CCA TGC ACA TTA TCT
met trp thr thr pro pro leu cys leu glu pro cys thr leu ser 585
TTT ACT GAA ATG GAA AAG AAT AAT TTA CTT CTG AAA TGG GAT TTT
phe thr glu met glu lys asn asn leu leu leu lys trp asp phe 600
GAC AAC AGA CCA CAC ATT TTG CAT GGT GAA TAT ATT GAG TTT ATT
asp asn arg pro his ile leu his gly glu tyr ile glu phe ile 615
TGT AGA GGA GAT ACT TAT CCA GCT GAA TTA TAT ATT ACT GGA TCT
cys arg gly asp thr tyr pro ala glu leu tyr ile thr gly ser 630
ATA CTT AGA ATG CAA TGT GAC AGA GGG CAG TTA AAA TAT CCA AGA
ile leu arg met gln cys asp arg gly gln leu lys tyr pro arg 645
TGT ATT CCA AGA CAA AGC ACT CTG TCT TAT CAA GAA CCC TTA AGA
cys ile pro arg gln ser thr leu ser tyr gln glu pro leu arg 660
ACA TAG
thr ter
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