Рис. F 13b seq

            Нуклеотидная и аминокислотная последовательности
                   гена фактора  XIIIb человека.                           
                                           
   -20
   ATG AGG TTG AAA AAC CTG ACT TTT ATC ATC ATA TTG ATA ATC TCA
   met arg leu lys asn leu thr phe ile ile ile leu ile ile ser  15

                       +1
   GGA GAA CTC TAT GCA GAA GAG AAA CCC TGT GGT TTT CCT CAT GTG
   gly glu leu tyr ala glu glu lys pro cys gly phe pro his val  30

   GAA AAT GGA AGA ATT GCC CAA TAT TAC TAT ACT TTT AAA AGC TTT
   glu asn gly arg ile ala gln tyr tyr tyr thr phe lys ser phe  45

   TAC TTT CCA ATG AGC ATA GAC AAA AAA TTG TCA TTT TTC TGC TTG
   tyr phe pro met ser ile asp lys lys leu ser phe phe cys leu  60

   GCT GGT TAT ACC ACT GAA AGT GGA AGA CAA GAA GAG CAA ACC ACG
   ala gly tyr thr thr glu ser gly arg gln glu glu gln thr thr  75

   TGT ACA ACA GAA GGC TGG TCT CCA GAG CCA AGG TGC TTC AAA AAA
   cys thr thr glu gly trp ser pro glu pro arg cys phe lys lys  90

   TGC ACT AAG CCT GAC CTG AGT AAT GGT TAC ATC TCT GAT GTA AAG
   cys thr lys pro asp leu ser asn gly tyr ile ser asp val lys 105

   TTA TTG TAT AAA ATT CAA GAG AAC ATG CAT TAT GGT TGC GCT TCA
   leu leu tyr lys ile gln glu asn met his tyr gly cys ala ser 120

   GGG TAC AAA ACC ACT GGA GGG AAG GAT GAA GAA GTG GTT CAA TGT
   gly tyr lys thr thr gly gly lys asp glu glu val val gln cys 135

   CTC TCT GAT GGA TGG TCT TCT CAA CCA ACC TGT AGG AAA GAA CAT
   leu ser asp gly trp ser ser gln pro thr cys arg lys glu his 150

   GAA ACG TGT TTG GCT CCT GAA TTA TAT AAT GGA AAT TAT TCC ACA
   glu thr cys leu ala pro glu leu tyr asn gly asn tyr ser thr 165

   ACA CAG AAA ACA TTC AAA GTG AAG GAC AAA GTA CAA TAC GAA TGT
   thr gln lys thr phe lys val lys asp lys val gln tyr glu cys 180

   GCT ACT GGC TAC TAC ACA GCT GGA GGA AAG AAG ACA GAG GAG GTA
   ala thr gly tyr tyr thr ala gly gly lys lys thr glu glu val 195

   GAA TGT CTC ACA TAC GGA TGG TCT CTC ACA CCA AAA TGT ACC AAA
   glu cys leu thr tyr gly trp ser leu thr pro lys cys thr lys 210

   TTA AAG TGC TCT TCT TTA AGA TTA ATT GAA AAT GGT TAT TTT CAT
   leu lys cys ser ser leu arg leu ile glu asn gly tyr phe his 225

   CCT GTA AAG CAA ACC TAT GAA GAA GGA GAT GTC GTT CAG TTT TTC
   pro val lys gln thr tyr glu glu gly asp val val gln phe phe 240

   TGT CAT GAA AAT TAT TAT CTA AGT GGA TCT GAT TTA ATT CAA TGC
   cys his glu asn tyr tyr leu ser gly ser asp leu ile gln cys 255

   TAT AAC TTT GGT TGG TAC CCA GAA TCT CCT GTA TGC GAA GGA AGA
   tyr asn phe gly trp tyr pro glu ser pro val cys glu gly arg 270

   AGA AAC AGA TGT CCT CCT CCA CCT CTG CCC ATA AAC TCC AAA ATT
   arg asn arg cys pro pro pro pro leu pro ile asn ser lys ile 285

   CAA ACA CAT TCA ACA ACT TAT CGT CAT GGA GAA ATA GTT CAT ATA
   gln thr his ser thr thr tyr arg his gly glu ile val his ile 300

   GAA TGT GAA CTT AAT TTT GAG ATC CAT GGG TCA GCA GAA ATA CGT
   glu cys glu leu asn phe glu ile his gly ser ala glu ile arg 315

   TGT GAA GAT GGA AAA TCG ACA GAA CCT CCA AAA TGC ATT GAA GGA
   cys glu asp gly lys ser thr glu pro pro lys cys ile glu gly 330

   CAG GAG AAG GTA GCC TGT GAG GAA CCA CCC TTC ATT GAA AAT GGT
   gln glu lys val ala cys glu glu pro pro phe ile glu asn gly 345

   GCA GCA AAT TTA CAC TCT AAG ATT TAT TAC AAT GGG GAT AAA GTG
   ala ala asn leu his ser lys ile tyr tyr asn gly asp lys val 360

   ACA TAT GCA TGT AAA AGC GGC TAC CTT CTC CAT GGA TCG AAT GAG
   thr tyr ala cys lys ser gly tyr leu leu his gly ser asn glu 375

   ATA ACT TGT AAT CGT GGA AAA TGG ACA CTT CCT CCT GAG TGT GTT
   ile thr cys asn arg gly lys trp thr leu pro pro glu cys val 390

   GAA AAT AAT GAG AAT TGT AAG CAT CCT CCT GTT GTA ATG AAT GGG
   glu asn asn glu asn cys lys his pro pro val val met asn gly 405

   GCT GTT GCA GAC GGG ATA TTG GCA AGC TAT GCA ACA GGA TCC TCA
   ala val ala asp gly ile leu ala ser tyr ala thr gly ser ser 420

   GTG GAA TAT AGA TGC AAT GAA TAT TAC TTA CTG AGG GGA TCA AAA
   val glu tyr arg cys asn glu tyr tyr leu leu arg gly ser lys 435

   ATA TCT CGT TGC GAA CAA GGA AAA TGG TCA TCC CCA CCT GTT TGC
   ile ser arg cys glu gln gly lys trp ser ser pro pro val cys 450

   TTG GAA CCA TGT ACT GTT AAT GTG GAT TAC ATG AAC AGA AAT AAC
   leu glu pro cys thr val asn val asp tyr met asn arg asn asn 465

   ATA GAA ATG AAG TGG AAA TAT GAA GGG AAA GTC TTA CAT GGA GAT
   ile glu met lys trp lys tyr glu gly lys val leu his gly asp 480

   TTA ATA GAT TTT GTA TGT AAA CAG GGA TAT GAC TTA TCT CCA TTA
   leu ile asp phe val cys lys gln gly tyr asp leu ser pro leu 495

   ACC CCA TTG TCT GAA TTA TCT GTG CAG TGC AAC AGA GGA GAA GTG
   thr pro leu ser glu leu ser val gln cys asn arg gly glu val 510

   AAA TAT CCT TTA TGT ACT AGA AAA GAA TCT AAA GGA ATG TGC ACA
   lys tyr pro leu cys thr arg lys glu ser lys gly met cys thr 525

   TCT CCT CCT CTT ATT AAA CAT GGA GTC ATT ATT AGT TCA ACA GTA
   ser pro pro leu ile lys his gly val ile ile ser ser thr val 540

   GAC ACC TAT GAA AAT GGC TCT TCA GTA GAA TAC AGA TGT TTT GAT
   asp thr tyr glu asn gly ser ser val glu tyr arg cys phe asp 555

   CAC CAT TTC CTA GAA GGA TCT AGG GAG GCC TAT TGT TTA GAT GGA
   his his phe leu glu gly ser arg glu ala tyr cys leu asp gly 570

   ATG TGG ACT ACA CCA CCA TTG TGT TTA GAG CCA TGC ACA TTA TCT
   met trp thr thr pro pro leu cys leu glu pro cys thr leu ser 585

   TTT ACT GAA ATG GAA AAG AAT AAT TTA CTT CTG AAA TGG GAT TTT
   phe thr glu met glu lys asn asn leu leu leu lys trp asp phe 600

   GAC AAC AGA CCA CAC ATT TTG CAT GGT GAA TAT ATT GAG TTT ATT
   asp asn arg pro his ile leu his gly glu tyr ile glu phe ile 615

   TGT AGA GGA GAT ACT TAT CCA GCT GAA TTA TAT ATT ACT GGA TCT
   cys arg gly asp thr tyr pro ala glu leu tyr ile thr gly ser 630

   ATA CTT AGA ATG CAA TGT GAC AGA GGG CAG TTA AAA TAT CCA AGA
   ile leu arg met gln cys asp arg gly gln leu lys tyr pro arg 645

   TGT ATT CCA AGA CAA AGC ACT CTG TCT TAT CAA GAA CCC TTA AGA
   cys ile pro arg gln ser thr leu ser tyr gln glu pro leu arg 660

   ACA TAG
   thr ter

Ссылки: