Granulocyte Colony-Stimulating Factor and Its Receptor

N. M. Pustoshilova, N. I. Putintseva, V. P. Romanov, L. R. Lebedev

Research Design and Technology Institute of Biologically Active Substances,

State Research Center of Virology and Biotechnology "Vector", Berdsk,

Novosibirsk oblast, Russia Granulocyte colony-stimulating factor (G-CSF) is the major growth factor responsible for regulating in vivo granulopoiesis and is used to treat neutropenia. Biological effects of G-CSF are mediated through the G-CSF receptor (G-CSFR), which forms active homooligomeric complexes upon ligand binding. This review summarized the current knowledge of the ligand-receptor complex structure, function, and signaling mechanisms of the G-CSFR. It also addresses the molecular mechanisms of disorders of granulopoiesis. These data are likely to be important in the development of novel hematologic drugs and treatment strategies.