Gene: [00.0/PDK1] pyruvate dehydrogenase kinase, isoenzyme 1;
|
FUN |
Pyruvate dehydrogenase kinase phosphorylates a mitochondrial pyruvate dehydrogenase (see GEM:0Xp221/PDHA1), causes inactivation of this multienzyme complex and inhibits the oxidative decarboxylation of pyruvate." |
|
FAG |
Other genes coding for pyruvate dehydrogenase kinase isoenzymes have been found: GEM:00.0/PDK2; GEM:00.0/PDK3; GEM:07q213/PDK4." |
|
REF |
CLO,SEQ,FAG "Gudi R &: JBC, 270, N48, 28989-28994, 1995 CLO,RAT "Popov KM &: JBC, 268, N35, 26602-26606, 1993 FUN "Pullen N &: Science, 279, N5351, 707-710, 1998 |
|
KEY |
mito, carb, lip |
|
CLA |
coding, basic |
|
LOC |
RS |
|
MIM |
MIM: 602524 |
|
EZN |
ENZYME: 2.7.1.? |
