Gene: [00.0/PDK1] pyruvate dehydrogenase kinase, isoenzyme 1;

FUN

Pyruvate dehydrogenase kinase phosphorylates a mitochondrial pyruvate dehydrogenase (see GEM:0Xp221/PDHA1), causes inactivation of this multienzyme complex and inhibits the oxidative decarboxylation of pyruvate."

FAG

Other genes coding for pyruvate dehydrogenase kinase isoenzymes have been found: GEM:00.0/PDK2; GEM:00.0/PDK3; GEM:07q213/PDK4."

REF

CLO,SEQ,FAG "Gudi R &: JBC, 270, N48, 28989-28994, 1995
CLO,RAT "Popov KM &: JBC, 268, N35, 26602-26606, 1993
FUN "Pullen N &: Science, 279, N5351, 707-710, 1998

KEY

mito, carb, lip

CLA

coding, basic

LOC

RS

MIM

MIM: 602524

EZN

ENZYME: 2.7.1.?