Gene: [00.0/PLKG] plakoglobin (common junctional plaque protein);
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GEN |
The primary polypeptide product contains 744 amino acid residues (MM 81.75 kD) and is translated from a single mRNA species (3.4 kb), although a minor mRNA species (3.7 kb) also occurs in some tumor cells. This minor mRNA has a 297-bp insertion in the 3'-unt region." |
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MOP |
Plakoglobin is an intracellular protein representing the main structural component of so called subplasmalemmal 'densities' or submembranous 'plaques'. It occurs as either the membrane-associated form (in the desmosome plaques formed by intermediate filaments or in the actin plaques formed by microfilaments) or the soluble (cytoplasmic) 7S form, which constitutes up to 30% of the total plakoglobin content." |
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REF |
PRO,SEQ,EVO "Franke WW &: PNAS, 86, N11, 4027-4031, 1989 |
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KEY |
cysk |
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CLA |
coding, basic |
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LOC |
RS |
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MIM |
? |
