Gene: [00.0/PTPN8] protein tyrosine phosphatase, non-receptor type 8 (PEST-containing);

PEP

[1] PTPN8 cDNA was shown to contain a large carboxy-terminal domain of approximately 500 amino acids that is rich in PEST (proline, glutamic acid, serine, and threonine) motifs. Such domains are characteristic of proteins that are rapidly degraded. The PTPN8 cDNA was found to code for an 802-amino acid protein with a predicted molecular weight of 89.7 kDa (Matthews-1992).
[2] The amino acid sequence of the phosphatase domain was about 35% similar to the phosphatase domains of other PTPases (FAM:PTP/00.0)."

FUN

[1] Systematic name: protein-tyrosine-phosphate phosphohydrolase.
[2]-Reaction catalyzed: protein tyrosine phosphate + H(2)O = protein tyrosine + orthophosphate."

REL

See GEM:20q13/PTPN1.

REF

COD,SEQ,FAG "Matthews RJ &: Mol Cell Biol, 12, 2396-2405, 1992

KEY

pep

CLA

coding, basic

LOC

RS

MIM

MIM: 600716

EZN

ENZYME: 3.1.3.48