Gene: [01p2/F3] coagulation factor III (thromboplastin, tissue factor); thromboplastin, tissue factor; [TF HTF ]

FUN

TF3 is the cell membrane glycoprotein - a lipid-dependent activation cofactor for factors IX and X. In the presence of F3 ). In addition, the complex activates factor X indirectly (via the internal pathway), taking part in the convertion of factor IX into its active form, IXa (in the presence of Ca++ and factor XIa)."

REF

LOC,CYG "Carson SD &: CCG, 40 (HGM8), N1-4, 600, 1985a
LOC,CYG "Carson SD &: Science, 229, (6 Sep), 991-993, 1985b
LOC,LIN "Dracopoli NC &: Genomics, 9, N4 (Apr), 686-700, 1991
PRO,SEQ,EXP,MOP "Fisher KL &: Thromb Res, 48, 89-99, 1987
LOC,PRO "Kao FT &: Somat Cell Mol Genet, 14, 407-410, 1988
PRO,HIS "Konigsberg WH &: Cell, 52, (11 Mar), 639-640, 1988
CLO,SEQ,EXP "Mackman N &: Biochemistry, 28, 1755-1762, 1989
PRO,SEQ,EXP,MOP "Morrissey JH &: Fed Proc, 46, 716, 1987a
PRO,SEQ,EXP,MOP "Morrissey JH &: Fed Proc, 46, (corrections), 2338, 1987b
PRO,SEQ,EXP,MOP "Morrissey JH &: Cell, 50, 129-135, 1987c
PRO,SEQ,EXP,LOC "Scarpati EM &: Biochemistry, 26, 5234-5238, 1987
PRO,SEQ,EXP,MOP "Spicer EK &: PNAS, 84, N15, 5148-5152, 1987

SWI

SWISSPROT: P13726

KEY

hem, clot, mem

CLA

coding, basic

LOC

01 p2

MIM

MIM: 134390

SYN

TF HTF

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