Gene: [01p341/HDAC1] histone deacetylase 1; reduced potassium dependency, yeast, homolog-like 1 (RPD3-like 1); [HD1 RPD3L1 ]
COM | The HDAC1 gene was mapped to chromosome 1p34.1 by fluorescence in situ hybridization (Furukawa-1996). Randhawa et al. assigned the HDAC1 gene to neighbor region of the same chromosome 1p34.3 (Randhawa-1998)." |
FUN | The acetylation/deacetylation of histones (see FAM:HIS/00.0) is involved in regulating chromatin structural dynamics, transcriptional regulation and cell cycle progression (Lee-1993; Taunton-1996; Wolffe-1996)." |
FAG | The following genes coding for histone deacetylase isoforms have been found: GEM:06q2/HDAC2; GEM:00.0/HDAC3." |
REF | CLO,SEQ,LOC "Furukawa
Y &: CCG, 73, 130-133, 1996 EXP,MEB,FUN "Lee DY &: Cell, 72, 73-84, 1993 LOC,FAG "Randhawa GS &: Genomics, 51, 262-269, 1998 CLO,SEQ "Taunton J &: Science, 272, 408-411, 1996 REV,FUN,EXP,EVO,FAG "Wolffe AP: Science, 272, N5260, 371-372, 1996 |
KEY | chr, trc, pep |
CLA | coding, basic |
LOC | 01 p34.1 |
MIM | MIM: 601241 |
SYN | HD1 RPD3L1 |
