Gene: [01p341/HDAC1] histone deacetylase 1; reduced potassium dependency, yeast, homolog-like 1 (RPD3-like 1); [HD1 RPD3L1 ]

COM

The HDAC1 gene was mapped to chromosome 1p34.1 by fluorescence in situ hybridization (Furukawa-1996). Randhawa et al. assigned the HDAC1 gene to neighbor region of the same chromosome 1p34.3 (Randhawa-1998)."

FUN

The acetylation/deacetylation of histones (see FAM:HIS/00.0) is involved in regulating chromatin structural dynamics, transcriptional regulation and cell cycle progression (Lee-1993; Taunton-1996; Wolffe-1996)."

FAG

The following genes coding for histone deacetylase isoforms have been found: GEM:06q2/HDAC2; GEM:00.0/HDAC3."

REF

CLO,SEQ,LOC "Furukawa Y &: CCG, 73, 130-133, 1996
EXP,MEB,FUN "Lee DY &: Cell, 72, 73-84, 1993
LOC,FAG "Randhawa GS &: Genomics, 51, 262-269, 1998
CLO,SEQ "Taunton J &: Science, 272, 408-411, 1996
REV,FUN,EXP,EVO,FAG "Wolffe AP: Science, 272, N5260, 371-372, 1996

KEY

chr, trc, pep

CLA

coding, basic

LOC

01 p34.1

MIM

MIM: 601241

SYN

HD1 RPD3L1

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