Gene: [01p36/HVEM] herpes virus entry mediator; [TR2 ATAR ]
|
FUN |
[1] HVEM is suggested to play an important role in herpesvirus
pathogenesis
because it enhanced the entry of several wildtype HSV strains of both
serotypes into CHO cells, and mediated HSV entry into activated human
T cells (Montgomery-1996).
[2] In vivo, epitope-tagged HVEM interacts with several TNFR-associated factor (TRAF) proteins, including TRAF1 (GEM:09q3/TRAF1), TRAF2 (GEM:00.0/TRAF2), TRAF3 (GEM:00.0/TRAF3), and TRAF5 (GEM:01q32/TRAF5). HVEM is linked via TRAFs to signal transduction pathways that activate the immune response (Marsters-1997)." |
|
MOP |
The HVEM gene is a member of the TNFR family (see GEM:12p13/TNFR1). The HVEM protein contains N-terminal signal peptide, 2 potential sites for addition of N-linked glycans, a putative membrane-spanning domain, and a cysteine-rich repeat region characteristic of TNFR famil members, and shared 17 to 25% amino acid identity with other TNFRs (Montgomery-1996)." |
|
REF |
CLO,EXP "Hsu H &: JBC, 272, N21, 13471-13474, 1997 CLO,EXP,LOC "Kwon BS &: JBC, 272, N22, 14272-14276, 1997 EXP,FUN "Masters SA &: JBC, 272, N22, 14029-14032, 1997 CLO,SEQ,MOP,FUN "Montgomery RI &: Cell, 87, N3, 427-436, 1996 |
|
KEY |
recp, vir, imm |
|
CLA |
coding, basic |
|
LOC |
01 p36.3-.22 |
|
MIM |
MIM: 602746 |
|
SYN |
TR2 ATAR |
