Gene: [01p36/ILA] interleukin-activated receptor, homolog of mouse Ly63; antigen CD137 (induced by lymphocyte activation; ILA); [CD137 Ly63 ]
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COM |
The CD137/ILA gene was localized to Chr 1p36 by somatic cell hybrid analysis (Schwarz-1997)." |
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FUN |
CD137 inhibits proliferation of activated T lymphocytes and induces programmed cell death (Schwarz-1996)." |
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MOP |
The CD137 gene encodes a 255-amino acid protein with 3 cysteine-rich motifs in the extracellular domain, a transmembrane region, and a short N-terminal cytoplasmic portion containing potential phosphorylation sites." |
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FAG |
CD137 is a member of the tumor necrosis factor receptor family (see GEM:12p13/TNFR1). Members of this receptor family and their structurally related ligands are important regulators of a wide variety of physiologic processes and play an important role in the regulation of immune responses. ILA is expressed by activated T- and B-lymphocytes and monocytes." |
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REF |
SEQ,EVO,LOC "Schwarz H &: BBRC, 235, N3, 699-703, 1997 COD,EXP "Schwarz H &: Blood, 87, N7, 2839-2845, 1996 CLO,EXP,FUN "Schwarz H &: Gene, 134, N2, 295-298, 1993 |
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KEY |
recp, mem, onc |
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CLA |
coding, basic |
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LOC |
01 p36 |
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MIM |
MIM: 602250 |
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SYN |
CD137 Ly63 |
