Gene: [01q21/IGHGR1A] immunoglobulin G Fc-receptor Ia (high-affinity); high-affinity p72 Fc/gamma-R protein (IgG receptor Ia); [FCGR1A FCGR1 ]
|
FAG |
[1] Two other IgG Fc receptors (low-affinity) have been identified and
mapped: Fc-gamma II (protein p40; GEM:01q23/IGHGR2A) and Fc-gamma III
(protein p50-70; GEM:01q23/IGHGR3A). Their
cDNAs are cloned. All the
three proteins belong to the multigene superfamily of
immunoglobulin-like peptides; see FAM:IMM/00.0.
[2] The following IgG Fc receptors are identified: high-affinity 1 receptor (Fc-gamma I, protein 72; this gene, as well as GEM:01p12/IGHGR1B, GEM:01q21/IGHGR1C); low-affinity 2 receptor (Fc-gamma II, protein p40; see GEM:01q23/IGHGR2A and GEM:01q23/IGHGR2B); low-affinity 3 receptor (Fc-gamma III, protein p50-70; see GEM:01q23/IGHGR3A and GEM:01q23/IGHGR3B)." |
|
PAT |
Alterations of the structure or expression of IGHG receptors are probably involved in pathogenesis of systemic lupus erythematosis (Frank-1979)." |
|
HIS |
CCM92 name: Fc fragment of IgG, high affinity Ia, receptor for (CD64) |
|
REF |
REV,FUN,PEP "Anderson CL: J Exp Med, 156, N6, 1794-1805, 1982 CLO,SEQ "de Wit TP &: Immunogenetics, 38, 57-59, 1993 CLO,SEQ "Ernst LK &: JBC, 267, 15692-15700, 1992 REV,FUN,PEP "Fleit &: PNAS, 79, 3275-3279, 1982 COM,PAT "Frank &: New Engl J Med, 300, 518-523, 1979 REV,FUN,PEP "Looney RJ &: J Immunol, 136, N5, 1641-1647, 1986 LOC "Maresco DL &: CCG, 73, 157-163, 1996 CLO,LOC,EAG,HUM,MOU "Osman N &: J Immunol, 148, N5, 1570-1575, 1992 CLO,SEQ "Takai S &: Hum Genet, 93, 13-15, 1994 REV,FUN,PEP "Unkeless &: Adv Immunol, 31, 247-270, 1981 CLO,SEQ "van de Winkel &: J Immunol, 154, 2896-2903, 1995 REV,FUN,STR,MOL,TRC "Yodoi, Kawabe: Res Immunol, 41, N1, 59-108, 1990 |
|
KEY |
imm, img, recp |
|
CLA |
coding, basic |
|
LOC |
01 q21 |
|
MIM |
MIM: 146760 |
|
SYN |
FCGR1A FCGR1 |
