Gene: [01q21/IVL] involucrin;
|
COM |
According to Stroh-1987, the most probable location for IVL is 1q21-22 (the major hybridization signal in q21); however, an additional minor signal site exists, 1p35-36 (where a paralogous sequence is probably located; see GEM:01p3/IVLL)." |
|
GEN |
The primary translation product is encoded by the only exon and consists of 585 amino acid residues, 2/3 of which (390 residues that form an internal region) represent a decapeptide repeated 39 times." |
|
EVO |
The internal region of IVL (which is a decapeptide repeat) of humans and higher primates substantially differs in length from that of lower primates, although 5'- and 3'-ancestral flanks a very similar in all primates. Thus, IVL represents an example of a gene with specific evolutionary history in higher primates and human." |
|
REF |
PRO,SEQ,EXP,MOP,GEN,STR "Eckert RL, Green: Cell, 46, 583-589, 1986 GEN,SEQ,POL,MUT "Simon M &: AJHG, 45, 910-916, 1989 LOC,CYG,MOL,PRO "Stroh &: CCG, 46, (HGM9), 700, 1987 GEN,STR,EVO,PRI "Teumer, Green: PNAS, 86, N4, 1283-1286, 1989 |
|
KEY |
cysk |
|
CLA |
coding, basic |
|
LOC |
01 q21 |
|
MIM |
MIM: 147360 |
