Gene: [01q21/PIK4CB] phosphatidylinositol 4-kinase, catalytic, beta; phosphatidylinositol 4-kinase, type III (wortmannin-sensitive);
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COM |
The PIK4CB gene was mapped to 1q21 by somatic cell hybrid analysis, radiation hybrid analysis, and FISH (Saito-1997; Suzuki-1997)." |
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FUN |
Phosphatidylinositol 4-kinases catalyze the synthesis of phosphatidylinositol-4-phosphate, the immediate precursor of phosphatidylinositol-4,5-diphosphate (Meyers-1997). The PIK4CB enzyme is inhibited by 150 nM wortmannin and is responsible for regulating the synthesis of agonist-sensitive pools of polyphosphoinositides (Nakanishi-1995)." |
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REF |
COD,SEQ,PEP "Meyers R, Cantley LC: JBC, 272, N7, 4384-4390, 1997 FUN,MEB,EXP "Nakanishi S &: PNAS, 92, 5317-5321, 1995 CLO,SEQ,LOC "Saito T &: DNA Res, 4, N4, 301-305, 1997 CLO,SEQ,LOC "Suzuki K &: DNA Res, 4, 273-280, 1997 |
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KEY |
lip, neu |
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CLA |
coding, basic |
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LOC |
01 q21 |
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MIM |
MIM: 602758 |
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EZN |
ENZYME: 2.7.1.67 |
