Gene: [02p16/XPO1] exportin 1 (required for chromosome region maintenance; CRM1, yeast, homolog); [CRM1 ]
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COM |
[1] The XPO1 gene was mapped to Chr 2p16 by FISH (Fornerod-1997).
[2] CRM1, or XPO1, is the homolog of yeast crm1 (named for 'required for chromosome region maintenance'), a nuclear protein essential for proliferation and chromosome region maintenance." |
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FUN |
CRM1 protein binds CAN and NUP88 (GEM:17p13/NUP88), and its association with the nuclear pore is dynamic. CRM1 is an export receptor for leucine-rich nuclear export signals (Fornerod-1997b)." |
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REF |
COD "Fornerod M &: Cell, 90, 1051-1060, 1997a LOC,FAG "Fornerod M &: Genomics, 42, 538-540, 1997b COD,SEQ "Kudo N &: JBC, 272, 29742-29751, 1997 COD,FUN "Stade K &: Cell, 90, 1041-1050, 1997 REV "Ullman KS &: Cell, 90, 967-970, 1997 |
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KEY |
chr |
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CLA |
coding, basic |
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LOC |
02 p16 |
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MIM |
MIM: 602559 |
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SYN |
CRM1 |
