Gene: [02q1/BUB1] budding uninhibited by benzimidazoles 1 (yeast homolog); mitotic checkpoint protein kinase BUB1; colorectal cancer with chromosomal instability;

COM

[1] The BUB1 gene was mapped to Chr 2q12-14 by fluorescence in situ hybridization (Cahill-1998).
[2] BUB1 is a prototype member of a family of genes, some of which encode proteins that bind to the kinetochore and all of which are required for a normal mitotic delay in response to spindle disruption."

DOM

The BUB1 protein contains 2 highly conserved domains: CD1 and CD2. CD1 directs kinetochore localization and binding to Bub3 (GEM:10q24/BUB3), whereas CD2 encodes the kinase domain."

REL

GEM:15q/BUB1B.

REF

COD,SEQ,LOC,MUT,DOM "Cahill DP &: Nature, 392, N6673, 300-303, 1998
CLO,SEQ,EXP,LOC "Pangilinan F &: Genomics, 46, N3, 379-388, 1997

KEY

onc

CLA

coding, basic

LOC

02 q12-14

MIM

MIM: 602452

EZN

?

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