Gene: [02q2/ACVR1] activin A receptor, type I (65kD); activin A receptor, type II-like kinase 2;

COM

The ACVR1 gene was mapped to Chr 2q23-q24 by fluorescence in situ hybridization (Roijer-1998)."

FAG

[1] There are 2 classes of activin receptors, type I and type II. identified 2 types of activin receptors (Mathews-1991). The type I receptor has a molecular size of 65 kD, while the molecular size of the type II receptor (see GEM:00.0/ACVR2A) is 85 kD.
[2] About activins see FAM:INH/00.0."

MOP

ACVR1 protein comprises a ligand-binding extracellular domain, a single membrane-spanning domain, and an intracellular kinase domain with predicted serine/threonine specificity (Mathews-1991). Human ACVR1/ALK2 cDNA clones encode 4 putative transmembrane ser/thr kinases (ten Dijke-1993)."

REF

CLO,FUN "Attisano L &: Cell, 75, N4, 671-680, 1993
COD,SEQ,EXP,FUN,FAG "Mathews LS, Vale WW : Cell, 65, 973-982, 1991
PRO,REL,SEQ "Matsuzaki K &: JBC, 268, 12719-12723, 1993
LOC,FAG "Roijer E &: Mammal Genome, 9, 266-268, 1998
PRO,SEQ,FAG,REL,TIS "ten Dijke P &: Oncogene, 8, 2879-2887, 1993

SWI

SWISSPROT: Q04771

KEY

recp

CLA

coding, basic

LOC

02 q23-24

MIM

MIM: 102576

EZN

ENZYME: 2.7.1.37

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