Gene: [02q32/CHRNA1] cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle); [CHRNA ACHRA ]
|
COM |
The GDB indicates a less definite localization - 2q24-32 - for CHRNA1 (GDB:G00-120-586:LOC='02 q24-32'); however, according to Beeson et al., the subsegment q32 is the most probable localization for this gene (Beeson-1989)." |
|
FAG |
[1] More than 10 genes that code for nicotinic cholinergic receptors
have been found:
(1) those predominantly expressed in neuromuscular junctions: the genes for alpha, delta, and gamma peptides of the nicotinic receptor form a syntenic group in chromosome 2q (GEM:02q3/CHRND and GEM:02q21/CHRNG), while the gene for beta peptide is located in chromosome 17p (GEM:17p1/CHRNB1); (2) those expressed in neurons: GEM:08p21/CHRNA2; GEM:15q24/CHRNA3; GEM:20q13/CHRNA4; GEM:15q24/CHRNA5; GEM:00.0/CHRNA6; GEM:15q14/CHRNA7; GEM:01^/CHRNB2; GEM:08p112/CHRNB3; and GEM:15q24/CHRNB4; (3) that expressed in embryonal cells: GEM:17p1/CHRNE. [2] On the genes that code for muscarinic cholinergic receptor peptides, see GEM:11q1/CHRM1." |
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EAG |
It is assumed that all vertebrates have the neuronal class nicotinic cholinergic receptors, alpha as well as so called non-alpha peptides (see GEM:00.0/CHRNAL)." |
|
REF |
PRO,LOC,FAG "Beeson &: CCG, 51, (HGM10), 960, 1989 EAG,MAP "Heidmann O &: Science, 234, 866-888, 1986 GEN,SEQ,EXP "Noda M &: Nature, 305, 818-823, 1983 |
|
KEY |
neu, recp, mem, sign |
|
CLA |
coding, basic |
|
LOC |
02 q32 |
|
MIM |
MIM: 100690 |
|
SYN |
CHRNA ACHRA |
