Gene: [02q33/PTHR2] parathyroid hormone receptor 2; [PTHR2R ]

COM

By FISH, the PTHR2 gene was mapped to 2q33 (Usdin-1996).

MOP

The PTHR2 gene product is a 7-transmembrane-domain G protein-coupled receptor that selectively recognizes parathyroid hormone (GEM:11p15/PTH) and is member of a family of G protein-coupled receptors referred to as the secretin receptor family (Usdin-1995). PTHR2 is most similar (51% overall amino acid identity) to the PTH/PTHLH receptor 1 (GEM:03p21/PTHR1). The gene is most abundantly expressed in brain, pancreas, testis, and placenta. The physiologic role of PTHR2 and its possible role in disease remained to be determined."

REL

GEM:02q141/SCTR.

REF

LOC "Usdin TB &: Genomics, 37, N1, 140-141, 1996
COD,SEQ,EXP "Usdin TB &: JBC, 270, 15455-15458, 1995

KEY

recp, mem, horm

CLA

coding, basic

LOC

02 q33

MIM

MIM: 601469

SYN

PTHR2R

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