Gene: [02q3/SCYA20] small inducible cytokine subfamily A (Cys-Cys), member 20; beta-chemokine Exodus; macrophage inflammatory protein 3 alpha (MIP-3-alpha); liver and activation-regulated chemokine (LARC); [MIP3A LARC ]

COM

Hromas-1997 reported the cloning and characterization of a novel human chemokine that they termed 'Exodus' for its chemotactic properties. This novel chemokine is distantly related to other chemokines (e.g., 28% homology with MIP-1-alpha, see GEM:17q112/SCYA3) and shares several of their biologic activities."

EVO

The sequence homology, expression, and biologic activity indicated that Exodus represents a novel, divergent beta-chemokine."

EXP

Exodus is expressed preferentially in lymphocytes and monocytes, and its expression is markedly upregulated by mediators of inflammation such as tumor necrosis factor (see GEM:06p2133/TNFA) and lipopolysaccaride."

FUN

Purified synthetic Exodus was found to inhibit proliferation of myeloid progenitors in colony formation assays. Exodus also stimulated chemotaxis of peripheral blood mononuclear cells."

REF

CLO,SEQ,LOC "Hieshima K &: JBC, 272, N9, 5846-5853, 1997
COD,SEQ,EXP,FUN "Hromas R &: Blood, 89, 3315-3322, 1997
IDN "Rossi DL &: J Immunol, 158, N3, 1033-1036, 1997

SWI

SWISSPROT: P78556

KEY

imm, cyk

CLA

coding, basic

LOC

02 q33-37

MIM

MIM: 601960

SYN

MIP3A LARC

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