Gene: [02q/LCO] protooncogene LCO (liver cancer oncogene); hepatocellular carcinoma (HCC; protooncogene LCO); [LCA HCC ]
|
COM |
The original name of the gene, LCA - 'Liver Cancer' - was introduced by Ochiya-1986, the denotation 'LCO' was adopted in HGM9." |
|
FAG |
One of nine integration sites for hepatitis B virus have been mapped to chromosome 2. Therefore, a possible relationship between viral DNA integration and LCO 'activation' (Tokino-1988) should be elucidated. On the integration sites for hepatitis B virus, see GEM:11p13/HVBS1." |
|
PRO |
Probe lambda-36 contains a 10 kb BamHI fragment of gDNA from human hepatocellular carcinoma; the insert contains two Alu-sequences, one in the middle part (close to coordinate 5 kb) and the other in the 3'-end half (close to coordinate 8 kb); for the in situ hybridization on chromosome two subfragments were used (HindIII, 1.5 kb, and HindIII/EcoRI, 2.8 kb) from the 5'-half of the lambda-36 insert." |
|
REF |
FAG,COM "Nagaya &: Genes Dev, 1, 773-782, 1987 CLO,EXP,LOC,PRO "Ochiya T &: PNAS, 83, N14, 4993-4997, 1986 LOC,PRO "Tokino T &: CCG, 48, 63-64, 1988 |
|
KEY |
onc |
|
CLA |
coding, basic |
|
LOC |
02 q14-21 |
|
MIM |
MIM: 165320 |
|
SYN |
LCA HCC |
