Gene: [03p211/ALAS1] delta-aminolevulinate synthase 1 (housekeeping);

FUN

Systematic name: succinyl-CoA:glycine C-succinyl-transferase (decarboxylating). The reaction catalyzed: succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2). Cofactor: piridoxalephosphate."

FAG

Gene for other isoform has been mapped: GEM:0Xp1121/ALAS2.

PRO

Probe pGEM-1 (a 1.7 kb cDNA fragment) was cloned at EcoRI site in plasmide pUC?"

REF

LOC,PRO "Astrin &: CCG, 46, (HGM9), 573, 1987
PRO,SEQ,EXP "Bawden MJ &: NAR, 15, 8563, 1987
CLO,SEQ "Bishop DF: NAR, 18, 7187-7187, 1991
CLO,LOC "Bishop DF &: Genomics, 7, 207-214, 1990
CLO,LOC "Cotter PD &: CCG, 69, 207-208, 1995
LOC,PRO "Sutherland GR &: AJHG, 43, 331-335, 1988

KEY

mito, aac, lip

CLA

coding, basic

LOC

03 p21.1

MIM

MIM: 125290

EZN

ENZYME: 2.3.1.37